Ana Cristina Fernandes is a Principal Researcher in Centro de Química Estrutural, a research institute from Instituto Superior Técnico (IST), in Lisbon.
Her research interests are organic chemistry, catalysis, sustainable chemistry and bioorganometallic chemistry. She investigated a new and complete reversal activity of high-valent oxo-rhenium and oxo-molybdenum complexes and demonstrated that they are excellent catalysts for X-H (X = Si, B, P) bond activation, for the reduction of several functional groups and for C-X (X = C, N, S, and P) bond forming reactions. Recently, she also demonstrated that oxo-rhenium and oxo-molybdenum complexes are efficient catalysts for biomass conversion.
She also investigated the synthesis of organometallic complexes containing carbohydrate moieties. She reported the synthesis of new ruthenium complexes containing carbohydrates moieties showing excellent cytotoxic activity on HeLa and colon HCT116 cancer cell lines, which are the first examples of Ru anticancer glycoconjugates with GLUT-mediated cellular uptake.