Ferreira IL

ORCID iD
orcid.org/0000-0001-6552-4479
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Alzheimer's disease,

Sources:
Ferreira IL (2014-01-12)

Huntington's disease,

Sources:
Ferreira IL (2014-01-12)

NMDA receptors,

Sources:
Ferreira IL (2014-01-12)

mitochondrial dysfunction

Sources:
Ferreira IL (2014-01-12)

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Scopus Author ID: 7102134994

Sources:
Scopus to ORCID (2013-11-18)

Biography

Ildete Luisa Ferreira received her undergraduate degree in Biochemistry in 1987 and the Master degree in Cellular Biology in 1993, at the University Coimbra. In 2003 she was awarded with her PhD in Cellular Biology, under the supervision of Prof. Arsélio Pato de Carvalho, at the Center for Neuroscience and Cell Biology (CNC) and Faculty of Science and Technology at Coimbra University. Her PhD thesis focused on the involvement of NMDA receptors in amacrine retinal cells degeneration under excitotoxic environments. After completing her PhD, IL Ferreira moved to the Department of Cell Biology of the University of Aveiro to implement neuronal and non-neuronal primary cultures techniques in order to test the effect of Abeta on APP trafficking, processing and secretion, using molecular and cell biology tools. In 2005 she returned to the CNC to work in the Mitochondrial Dysfunction and Cell Death group headed by Dr. A. Cristina Rego. Her main contributions to science is based on both basic neuroscience and models of neurodegeneration (e.g. excitotoxicity, oxidative stress and ischemia) as described in 35 publications, 2 book chapter, and in the participation in 17 scientific projects. The main contribution of her previous work was related with the understanding of the pathways by which calcium enters the cell and its role in the mechanisms of neurotransmission and neurodegeneration. More recently, as Assistant Investigator at ‘Ciência 2008’ Programme, her research has been focused on models of neurodegenerative disorders, namely Alzheimer’s and Huntington’s diseases, particularly on the analysis of mitochondrial dysfunction, oxidative stress and apoptosis, and the contribution of N-methyl-D-aspartate (NMDA) receptors subunits, namely GluN2A and GluN2B, in neuronal dysfunction in Alzheimer’s disease. During her career, she collaborated in the supervision of PhD students, MSc students, undergraduate students and laboratory rotations. She also collaborated in seminars for students, doctoral classes of the PDBEB, teaching courses of the degrees in Biology, Biochemistry and Integrated Master in Biomedical Engineering of the Faculty of Sciences and Technology, Pharmaceutical Sciences of the Faculty of Pharmacy, and also in the Intregated Master in Medicine, at the Faculty of Medicine, University of Coimbra, as well as in the course of Cell and Molecular Biology of the Master degree in Cell Biology. She was a member of the jury in 3 Master thesis defenses, being the main opponent in 2 of them and in 1 PhD thesis defense. In the near future she is particularly motivated to tackle the dysfunction of cortico-striatal glutamatergic synapses, the dynamics of NMDA receptor subunits in synaptic and extrasynaptic sites, as well as to evaluate the role of synaptic versus extrasynaptic receptors in modifying mitochondrial dynamics and biogenesis in the context of Huntington´s and Alzheimer’s diseases. In addition, she intends to continue to supervise master and PhD students and to participate in teaching activities within the University of Coimbra.
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