My lab is interested in understanding the nuclear and chromatin organization of pluripotency, stemness, and cancer. We use different models of pluripotency including preimplantation and early postimplantation stages of mammalian development, chicken primordial germ cells, and different pluripotent cell lines. Chromatin and nuclear organization have a central role in the control of transcription, and thus may significantly contribute to the regulation of differentiation. Organization of chromatin and chromosome territories within the nucleus of eukaryotic cells largely affects genome function. This is established through chromosome positioning, arrangement of chromatin loops, changes in chromatin fiber density, and formation and localization of nuclear bodies at chromosome neighborhoods. In addition, states of differentiation and function of the nucleus and chromatin can be regulated by many different intracellular signaling pathways.