Gian Gaetano Tartaglia received his MPhil in Theoretical Physics from the University of Rome La Sapienza in 2000 (Italy) with a thesis on mathematical modeling of neurons. He carried out his doctoral studies in Biochemistry at the University of Zurich (Switzerland) where he investigated principles of protein folding, misfolding and aggregation with special emphasis of neurodegenerative diseases. He then moved to the University of Cambridge (UK) as a Clare Hall post-doctoral fellow in the Departments of Chemistry (2005) and Genetics (2008). During this period, Gian worked under the supervision of Chris Dobson and Michele Vendruscolo and employed computational and experimental methods to study cell toxicity caused by formation of amyloid aggregates (funding: Swiss National Funds and Medical Research Council). Gian joined the Centre for Genomic Regulation (Spain) as group leader in 2010 and he started to investigate protein interactions with molecular chaperones and RNA molecules using a series of in silico, in vitro and in vivo approaches. He is life member of Clare Hall College (UK) since 2011. Gian’s group developed the first theoretical framework to predict protein interactions with RNA molecules and studies the role of non-coding transcripts in neurodegenerative diseases. He was appointed ICREA Professor of Life and Medical Sciences in 2014.