Research Description: Dr Carvalho’s research focuses on investigating the biological pathways involved in the role of glucocorticoid hormones and pro-inflammatory cytokines in the biological effects of stress, in the pathogenesis of depression and in the molecular mechanisms of antidepressant drugs.
Her projects more specifically revolve around four major themes:
1. The anti-inflammatory and neuroendocrine mechanism of action of antidepressant drugs
2. The antidepressant effect of anti-inflammatory drugs
3. The biological mechanisms involved in the pathogenesis of depression in people with inflammatory illnesses
4. Understanding how inflammatory molecules can signal the brain to alter cognitive function, behaviour and mood.
Research Theme: Translational pharmacology, Immunity and Inflammation, Mental Health, Neurosciences
Dr. Carvalho has received several prestigious awards including Young Investigator Awards from the National Alliance for Research in Schizophrenia and Depression (NARSAD), the European Neuropsychopharmacology Society (ECNP), the British Association for Psychopharmacology Non-clinical Award, and the American Psychosomatic Society. She is also associate Editor for Advances in Psychiatry.
Research & Teaching Profile
Research Interests: Psychological stress and inflammatory disease; Infection, immunity and depressive illness, mode of action of antidepressant drugs
Conditions: Cardiovascular disease, Major Depression, Inflammatory illnesses
Methods: Psychosocial research, self-report, laboratory testing of healthy volunteers and clinical groups, psychophysiological monitoring, anthropometric measures, ambulatory assessment, phlebotomy, ELISA, Luminex, affymetrix, quantitative RT-PCR, PBMC cell culture, cross-sectional analysis, biomarker identification, longitudinal analysis.