Paolo Bernardi

ORCID iD
orcid.org/0000-0001-9187-3736
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Italy

Sources:
Paolo Bernardi (2017-08-18)

  • Keywords
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Mitochondria,

Sources:
Paolo Bernardi (2017-08-18)

Channels,

Sources:
Paolo Bernardi (2017-08-18)

Permeability Transition,

Sources:
Paolo Bernardi (2017-08-18)

Calcium,

Sources:
Paolo Bernardi (2017-08-18)

Cell Death,

Sources:
Paolo Bernardi (2017-08-18)

Cyclophilins,

Sources:
Paolo Bernardi (2017-08-18)

Cyclophilin Inhibitors,

Sources:
Paolo Bernardi (2017-08-18)

Oxidative Stress

Sources:
Paolo Bernardi (2017-08-18)

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Institutional Site

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Paolo Bernardi (2017-08-18)

Google Scholar

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Paolo Bernardi (2017-08-18)

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ResearcherID: C-3656-2008

Sources:
Clarivate Analytics (2014-08-28)

Biography

I study mitochondria, with specific emphasis on the role of mitochondrial channels in cellular pathophysiology. A specific area of research is the calcium-dependent permeability transition pore (PTP), a high conductance channel that plays a key role in cell death. I carried out a thorough characterization of the PTP in isolated mitochondria, and defined key points of regulation (membrane potential, matrix pH, Me2+-binding sites, specific redox-sensitive sites). I then developed tools to reliably monitor mitochondrial function in situ, which allowed to address mechanistic questions related to PTP operation in intact cells and organs. These advances made it possible to ask the question of how modulation of mitochondrial function in situ can be exploited to force apoptosis in cancer cells and to prevent apoptosis in degenerative diseases, an area that is the current focus of my laboratory. In 2013 I made the key discovery that the PTP channel forms from the F-ATP synthase
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