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Employment (1)

National Institutes of Health: Bethesda, MD, US

2017-11 to present | Postdoc (National Cancer Institute)
Employment
Source: Self-asserted source
Yukun Guan

Education and qualifications (2)

Peking University: Beijing, Beijing, CN

2011-09 to 2017-07 | Ph.D. (School of Life Sciences )
Education
Source: Self-asserted source
Yukun Guan

Lanzhou University: Lanzhou, Gansu, CN

2007-09 to 2011-07 | Bachelor (School of Life Sciences )
Education
Source: Self-asserted source
Yukun Guan

Works (11)

New therapeutic target for alcohol-associated hepatitis (AH): AH-associated IL-8+neutrophils

eGastroenterology
2024-12 | Journal article
DOI: 10.1136/egastro-2024-100166
Contributors: Yukun Guan; Dechun Feng; Luca Maccioni; Yang Wang; Bin Gao
Source: check_circle
Crossref

Acute depletion of BRG1 reveals its primary function as an activator of transcription

Nature Communications
2024-05-29 | Journal article
DOI: 10.1038/s41467-024-48911-z
Contributors: Gang Ren; Wai Lim Ku; Guangzhe Ge; Jackson A. Hoffman; Jee Youn Kang; Qingsong Tang; Kairong Cui; Yong He; Yukun Guan; Bin Gao et al.
Source: check_circle
Crossref

IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis

Journal of Clinical Investigation
2024-05-01 | Journal article
DOI: 10.1172/JCI178616
Contributors: Yukun Guan; Brandon Peiffer; Dechun Feng; Maria A. Parra; Yang Wang; Yaojie Fu; Vijay H. Shah; Andrew M. Cameron; Zhaoli Sun; Bin Gao
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Crossref

Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models

Journal of Clinical Investigation
2023-08-01 | Journal article
DOI: 10.1172/JCI166954
Contributors: Dechun Feng; Xiaogang Xiang; Yukun Guan; Adrien Guillot; Hongkun Lu; Chingwen Chang; Yong He; Hua Wang; Hongna Pan; Cynthia Ju et al.
Source: check_circle
Crossref

Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners

Cellular & Molecular Immunology
2021-09 | Journal article
DOI: 10.1038/s41423-021-00731-7
Contributors: Yeni Ait Ahmed; Yaojie Fu; Robim M. Rodrigues; Yong He; Yukun Guan; Adrien Guillot; Ruixue Ren; Dechun Feng; Juan Hidalgo; Cynthia Ju et al.
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Crossref

Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING

Immunity
2021-05 | Journal article
DOI: 10.1016/j.immuni.2021.03.011
Contributors: Run Fang; Qifei Jiang; Yukun Guan; Pengfei Gao; Rui Zhang; Zhen Zhao; Zhengfan Jiang
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Crossref

Manganese salts function as potent adjuvants

Cellular & Molecular Immunology
2021-05-25 | Journal article
DOI: 10.1038/s41423-021-00669-w
Contributors: Rui Zhang; Chenguang Wang; Yukun Guan; Xiaoming Wei; Mengyin Sha; Mengran Yi; Miao Jing; Mengze Lv; Wen Guo; Jing Xu et al.
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Crossref

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Cell Research
2020-11-24 | Journal article
DOI: 10.1038/s41422-020-00395-4
Contributors: Mengze Lv; Meixia Chen; Rui Zhang; Wen Zhang; Chenguang Wang; Yan Zhang; Xiaoming Wei; Yukun Guan; Jiejie Liu; Kaichao Feng et al.
Source: check_circle
Crossref

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Immunity
2018-04 | Journal article
DOI: 10.1016/j.immuni.2018.03.017
Part of ISSN: 1074-7613
Contributors: Chenguang Wang; Yukun Guan; Mengze Lv; Rui Zhang; Zhaoying Guo; Xiaoming Wei; Xiaoxia Du; Jing Yang; Tong Li; Yi Wan et al.
Source: Self-asserted source
Yukun Guan via Crossref Metadata Search

MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner

PLOS Pathogens
2017-11-10 | Journal article
DOI: 10.1371/journal.ppat.1006720
Part of ISSN: 1553-7374
Contributors: Run Fang; Qifei Jiang; Xiang Zhou; Chenguang Wang; Yukun Guan; Jianli Tao; Jianzhong Xi; Ji-Ming Feng; Zhengfan Jiang; Pinghui Feng
Source: Self-asserted source
Yukun Guan via Crossref Metadata Search
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Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

Cell
2011-10 | Journal article
DOI: 10.1016/j.cell.2011.09.022
Part of ISSN: 0092-8674
Contributors: Huihui Chen; Hui Sun; Fuping You; Wenxiang Sun; Xiang Zhou; Lu Chen; Jing Yang; Yutao Wang; Hong Tang; Yukun Guan et al.
Source: Self-asserted source
Yukun Guan via Crossref Metadata Search
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