I'm the director and designated veterinarian of Center for Neuroscience and Cell Biology Animal Facilities. My goals are to continue the improvement of animal welfare, through an adequate husbandry and care during animal production and experimentation, and continued education of researchers and all involved in animal experimentation. I'm also interested in communicating what animal experimentation is to the general society .
My main area of scientific activity is Reproduction in particular alternatives to animal experimentation through the development of in vitro systems to discover the basics of spermatogenesis regulation, test compounds and eventually produce gametes.
Relying on the support of a FCT funded project "New strategies to recover fertility and genetic variability of endangered felids: development of xenografting and spermatogonial stem cell transplantation in domestic cat as model for endangered felids" PTDC/CVT/119477/2010, I have explored some state of the art methodologies such as xenografting and in vitro organ culture, both maintaining the architecture of the testicular tissue, to rescue the genetic potential of animals that die prematurely. Now my aims are to develop an in vitro system amenable to be used to reproduce in vitro the spermatogenic process of different species.
Other areas of work include:
- Participation in the project "Novel insights into the reproductive dysfunction in diabetes: 3D dimensional analysis of spermatogenesis and analysis of mitochondria status through Confocal Raman Microscopy"