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Employment (1)

University of Massachusetts Medical School: Worcester, MA, US

Associate Professor (Horae Gene Therapy Center)
Employment
Source: Self-asserted source
Jun

Works (17)

BCKDHA-BCKDHB digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease

Science Translational Medicine
2025-02-26 | Journal article | Author
DOI: 10.1126/scitranslmed.ads0539
Contributors: Qin Su; David Chuang; Erik G. Puffenberger; Ran He; Karlla Brigatti; Heather Gray-Edwards; Kevin Strauss; Zhong Jiang; Alisha Gruntman; Lingzhi Ren et al.
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AAAS - Science

AAV-RNAi constructs promote DRG toxicity

Molecular Therapy
2025-01 | Journal article
DOI: 10.1016/j.ymthe.2024.12.027
Contributors: Jun Xie; Phillip W.L. Tai
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Crossref

AAV5 Delivery of CRISPR/Cas9 Mediates Genome Editing in the Lungs of Young Rhesus Monkeys

Human Gene Therapy
2024-10-01 | Journal article
DOI: 10.1089/hum.2024.035
Contributors: Shun-Qing Liang; Andrew W. Navia; Michelle Ramseier; Xuntao Zhou; Michele Martinez; Charles Lee; Chen Zhou; Joae Wu; Jun Xie; Qin Su et al.
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Crossref

Potential limitations of microdystrophin gene therapy for Duchenne muscular dystrophy

JCI Insight
2024-06-10 | Journal article
DOI: 10.1172/jci.insight.165869
Contributors: Cora C. Hart; Young il Lee; Jun Xie; Guangping Gao; Brian L. Lin; David W. Hammers; H. Lee Sweeney
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Crossref

Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope

Nature Communications
2024-02-17 | Journal article
DOI: 10.1038/s41467-024-45763-5
Contributors: Nathan Bamidele; Han Zhang; Xiaolong Dong; Haoyang Cheng; Nicholas Gaston; Hailey Feinzig; Hanbing Cao; Karen Kelly; Jonathan K. Watts; Jun Xie et al.
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Crossref

Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope

2023-04-14 | Preprint
DOI: 10.1101/2023.04.14.536905
Contributors: Nathan Bamidele; Han Zhang; Xiaolong Dong; Nicholas Gaston; Haoyang Cheng; Karen Kelly; Jonathan K. Watts; Jun Xie; Guangping Gao; Erik J. Sontheimer
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Crossref

Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editingin vivo

2023-03-20 | Preprint
DOI: 10.1101/2023.03.20.533459
Contributors: Han Zhang; Karen Kelly; Jonathan Lee; Dimas Echeverria; David Cooper; Rebecca Panwala; Zexiang Chen; Nicholas Gaston; Gregory A. Newby; Jun Xie et al.
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Crossref

Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration

Nature Communications
2022-11-11 | Journal article
DOI: 10.1038/s41467-022-34694-8
Contributors: Chujiao Lin; Qiyuan Yang; Dongsheng Guo; Jun Xie; Yeon-Suk Yang; Sachin Chaugule; Ngoc DeSouza; Won-Taek Oh; Rui Li; Zhihao Chen et al.
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Crossref

Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery

Nature Communications
2022-10-19 | Journal article
DOI: 10.1038/s41467-022-33956-9
Contributors: Yeon-Suk Yang; Jung-Min Kim; Jun Xie; Sachin Chaugule; Chujiao Lin; Hong Ma; Edward Hsiao; Jaehyoung Hong; Hyonho Chun; Eileen M. Shore et al.
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Crossref

Suppression of Heterotopic Ossification in Fibrodysplasia Ossificans Progressiva Using AAV Gene Delivery

2022-06-10 | Preprint
DOI: 10.21203/rs.3.rs-1646941/v1
Contributors: Yeon-Suk Yang; Jung-Min Kim; Jun Xie; Sachin Chaugule; Chujiao Lin; Hong Ma; Edward Hsiao; Jaehyoung Hong; Hyunho Chun; Eileen Shore et al.
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Crossref

AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice

Nature
2022-04-14 | Journal article
DOI: 10.1038/s41586-022-04533-3
Contributors: Jiaming Wang; Yue Zhang; Craig A. Mendonca; Onur Yukselen; Khaja Muneeruddin; Lingzhi Ren; Jialing Liang; Chen Zhou; Jun Xie; Jia Li et al.
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Crossref

Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette

Molecular Therapy - Methods & Clinical Development
2021-12 | Journal article
DOI: 10.1016/j.omtm.2021.08.001
Contributors: Sandeep R.P. Kumar; Jun Xie; Shilang Hu; Jihye Ko; Qifeng Huang; Harrison C. Brown; Alok Srivastava; David M. Markusic; Christopher B. Doering; H. Trent Spencer et al.
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Crossref

Adenine Base Editing in vivo with a Single Adeno-Associated Virus Vector

2021-12-13 | Preprint
DOI: 10.1101/2021.12.13.472434
Contributors: Han Zhang; Nathan Bamidele; Pengpeng Liu; Ogooluwa Ojelabi; Xin D. Gao; Tomás Rodriguez; Haoyang Cheng; Jun Xie; Guangping Gao; Scot A. Wolfe et al.
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Crossref

Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency

Annals of Neurology
2021-10 | Journal article
DOI: 10.1002/ana.26185
Contributors: Carlos Lopez‐Gomez; Maria J. Sanchez‐Quintero; Eung Jeon Lee; Giulio Kleiner; Saba Tadesse; Jun Xie; Hasan Orhan Akman; Guangping Gao; Michio Hirano
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Crossref

Low-Dose Recombinant Adeno-Associated Virus-Mediated Inhibition of Vascular Endothelial Growth Factor Can Treat Neovascular Pathologies Without Inducing Retinal Vasculitis

Human Gene Therapy
2021-07-01 | Journal article
DOI: 10.1089/hum.2021.132
Contributors: Shun-Yun Cheng; Yongwen Luo; Anneliese Malachi; Jihye Ko; Qin Su; Jun Xie; Bo Tian; Haijiang Lin; Xiao Ke; Qiang Zheng et al.
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Crossref

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

Nature Cell Biology
2020-02 | Journal article
DOI: 10.1038/s41556-020-0463-6
Contributors: Wenjian Gan; Xiaoming Dai; Xiangpeng Dai; Jun Xie; Shasha Yin; Junjie Zhu; Chen Wang; Yuchen Liu; Jianping Guo; Min Wang et al.
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Crossref

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

Nature Communications
2019-07-04 | Journal article
DOI: 10.1038/s41467-019-10809-6
Contributors: Yeon-Suk Yang; Jun Xie; Dan Wang; Jung-Min Kim; Phillip W. L. Tai; Ellen Gravallese; Guangping Gao; Jae-Hyuck Shim
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Crossref

Peer review (13 reviews for 6 publications/grants)

Review activity for ACS infectious diseases. (2)
Review activity for ACS omega. (1)
Review activity for Gene therapy. (1)
Review activity for Molecular therapy (5)
Review activity for Molecular therapy. (3)
Review activity for Nature communications (1)
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