Margarida Casal

ORCID iD
orcid.org/0000-0002-0143-9758
  • Keywords
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Biology. Microbiology. Molecular biotechnology. Nano-biotechnology and smart materials. Protein structural and functional analysis.

Sources:
Margarida Casal (2013-12-12)

  • Websites
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cbma.bio.uminho.pt

Sources:
Margarida Casal (2015-07-27)

  • Other IDs
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ResearcherID: B-6386-2009

Sources:
Clarivate Analytics (2013-11-15)

Scopus Author ID: 7102313058

Sources:
Scopus to ORCID (2013-11-22)

Biography

Since 2013 I am the Head of the Centre of Molecular and Environmental Biology awarded by FCT with EXCELLENT in the 2013 Evaluation of R&D Units. As can be checked in my Google scholar profile (http://scholar.google.pt/citations?user=02W9yO4GjtsC&hl=pt-PT&oi=ao) or the ISI Web of Science (link to my researcher ID: http://www.researcherid.com/rid/B-6386-2009; and ORCID http://orcid.org/0000-0002-0143-9758, Scopus Author ID 7102313058) I published 102 ISI publications (first one published in 1995) that accumulate at the present time 2150 citations (ISI), which corresponds to an h-index of 26 (July 2016). I was invited as a speaker to 36 lectures in national and international symposia. I am Referee of 21 Journals indexed in ISI and Scopus. I have evaluated research projects submitted to funding agencies from Austria, Czech Republic and Belgium as well as from FCT, FP7 and IFS. I was elected President of the Genetics Portuguese Society and currently Vice-President. At the University of Minho I was elected President of the Pedagogic Council (2000 - 04), Head of the Biology Department (2006 – 12), member of the Scientific Council (2009 - ) and member of the Conselho Geral (2009 - 2016). I have supervised 8 pos-doc fellows (+ 1 ongoing), 14 doctoral dissertations (+2 ongoing, +1 co-supervision ongoing), 16 master theses (+ 2 ongoing) and 35 research fellows (in the scope of granted projects). I was main opponent in 28 PhD Juris (5 in Universities abroad) and 4 Habilitation Juris. I was appointed evaluator of 15 professors in the Department of Biology of UMinho. I have participated in 42 research projects (national and European) an Principal Investigator in 8 projects, raising a global funding over 5 MEuros. I graduated in Biology in 1985, and I have started my position at the Department of Biology of Minho University in February of 1986. Since then, both my scientific and teaching activities evolved together, being difficult to separate them. In the beginning of 90´s I started my PhD oriented towards Yeast Biology, and to the study of the physiology and molecular processes associated with the transport of nutrients through the plasma membrane. During my Post-doc I continued strongly determined in deepening my knowledge on Yeast Biology and Molecular Genetics which has culminated on the discovery of genes encoding monocarboxylic acid transporters Jen1 and Ady2 in yeast, and YaaH/SatP in bacteria. The adoption of the microorganisms as working models was crucial on the development of the laboratory of Molecular Biotechnology at the Department of Biology, University of Minho. The implementation of molecular genetics tools allowed me to approach biotechnological-oriented projects in areas like material sciences, enzyme modulation and biomedicine. Currently, my scientific interests are mostly centered on protein structural-functional analysis, aiming at understanding the molecular features that let them performing work in the cell. My interests are focused in 2 main topics: i) Structural-functional analysis of plasma membrane transporters. By using an assortment of biological materials, covering bacteria, yeasts and human cancer cells, the aim is to solve the structure of carboxylic acid permeases and understand how they work and selectively transport the substrates eg lactate, malate, citrate. ii) Recombinant protein-based polymers (rPBPs). The aim is to design, produce, characterize and develop applications for rPBPs inspired on the structure of silk and elastin, providing an extraordinary tool to create self-structured and “smart” (stimuli responsive) biopolymers. The use of rPBPs inspired on elastin and silk strutures is being oriented for biotechnology and biomedical applications, such as tissue engineering scaffolds. In 2012 I was founder and is currently partner of the spin-off company NanoDelivery, I&D in Bionanotechnology, Lda. Present positions - Dean of the Faculty of Sciences of the University of Minho, 2016 - present (elected). - Director of the Molecular and Environmental Biology Centre CBMA, 2013 – present (elected) http://cbma.bio.uminho.pt/ - Member of the Scientific Council of the Faculty of Sciences, 2009 – present (elected) - Member of the General Council (Conselho Geral), Universidade do Minho, 2009 - present (elected) - Vice-President of the "Sociedade Portuguesa de Genética", 2010-present (elected) - Full Professor - Professora Catedrática, School of Sciences, University of Minho, 2009 – present
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