PharmD in 2004, Faculty of Pharmacy, University of Coimbra.
PhD in 2010, Faculty of Pharmacy, University of Coimbra.
PhD in the development of targeted liposomes for drug and nucleic acids delivery.
Post-Doc in Stem cell-based therapies for neuroprotection and neuroregeneration.
Current research interests:
Neural/neuroepithelial stem cells sources: adult stem cells and stem cells derived from induced pluripotent stem cells (iPSC).
Transplantation of neural/neuroepithelial stem cells into Machado-Joseph disease mouse models as a promising neuroregenerative strategy for neurodegenerative diseases.
Use of iPSC-derived neural cultures as human in vitro models for drugs testing.
Viral vectors as tools for gene silencing in neurodegenerative diseases.
Combination of transplantation of neural stem cells and ataxin-3 protein downregulation into Machado-Joseph disease models. How the combination of different therapeutic strategies (stem cells transplantation and gene silencing of deleterious genes) can improve patients outcomes?
Brain-targeted liposomes for therapeutic molecules delivery.
Brain plasticity modulation.