Marcello Locatelli



Member of Italian Chemical Society (SCI), American Chemical Society (ACS), and Italian Phytochemical Society (SIF). From A.A. 2009 tenured of the channel (H-Z) of the course “Analytical Chemistry and Laboratory of Analytical Chemistry”, Specialistic Degree, Faculty of Pharmacy The research activities involved in development and validation of analytical method (follow the International Guide Lines as ICH) for qualitative and quantitative molecular determination in complex biological and environmental matrix (as serum, plasma, bile, liver and Hypothalamic tissue, kidney, faeces and urine), for structures valuations of natural and artificial chemical system with different complexity and aggregation state. In this contest, pay special attention to pre-analytical step as samples handling, extraction and purification procedures, separation methods, enrichment, application of HPLC-ESI-MS/MS combined method for the accurate, sensible and selective drug and metabolite determination that were difficult to determine with traditional detectors (as UV/Vis or ECD). This analytical procedures were applied to: glucosamine hydrochloride, 5-amino-salycilic acid, natural and synthetic bile acids, drug and its metabolites, in particular for pre-clinical study applications for the determination of pharmacological parameters, bioequivalence, absorption, distribution, metabolism and excretion (ADME). Now research line was implementing to development of predictive model applied to HPLC method for the determination of xenobiotics. Another scientific research area is the qualitative and quantitative evaluation (development and validation of new analytical assay) of natural compounds secondary metabolites were shown to exert in vitro and in vivo anti-cancer activity. Scientific activity was attested by publication on international journal, by oral and poster communication at international congress. Besides he is reviewer for international journals (Trends in Analytical Chemistry; Journal of Chromatography A; Talanta; Food Chemistry; Food and Chemical Toxicology, Instrumentation Science & Technology; Analytical Letters; Phytochemical Analysis; Environmental Science and Pollution Research; Oceanography; Environmental Science & Technology; Global Journal of Analytical Chemistry; Industrial & Engineering Chemistry Research; Chemistry Central Journal; Bioorganic & Medicinal Chemistry; Current Bioactive Compounds; Current Drug Safety; Current Organic Chemistry; Catalysis Letters; International Journal of Immunopathology and Pharmacology; Journal of Pharmacognosy and Phytotherapy; Molecules; Medicinal Chemistry; Mini-Review in Medicinal Chemistry; British Journal of Pharmaceutical Research; Preparative Biochemistry and Biotechnology). He's member of the Editorial Board of the journal “Current Bioactive Compounds” (Bentham Science Publisher), and "Pharmaceutica Analytica Acta" (Omics Publishing Group).

Record last modified Nov 8, 2018 11:07:56 AM