I am interested in understanding how the metabolic state of a cell determines cell fate. My research focuses on identifying metabolic and nutrient sensors, and understanding their roles in cell growth, division, survival or death. Areas of research in the lab include understanding how metabolism and translation are integrated, identifying new metabolic sensors/switches, and studying the metabolic basis of cooperation and communication in cell communities. I am particularly interested in metabolic sensing and signaling mechanisms during various nutrient limitations.
I am an Assistant Investigator at the Institute for Stem Cells and Regenerative Medicine (inStem), within the National Centre for Biological Sciences campus in Bangalore. Previously, I was a postdoctoral fellow in the Dept. of Biochemistry at UT Southwestern Medical Center, with Drs. Benjamin Tu and Steven McKnight. I completed my Ph.D. with Dr. Joseph Beavo at the University of Washington (Dept. of Pharmacology).
My research utilizes a broad range of approaches, including mass-spectrometry based metabolite analysis, yeast genetics, biochemistry, pharmacology and cell biology, and comparative proteomics and bioinformatics. You can read more about my work at http://sunillaxmanlab.weebly.com