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Skin aging, Fibroblasts and collagen, TGF-b signaling and MMPs, CCN family, Cell-matrix interaction and integrin, Stromal microenvironment and mechanotransduction.
Taihao Quan (2013-07-16)
Dr. Quan is a Research Associate Professor in the Department of Dermatology Photoaging and Aging Research Program at the University of Michigan, Ann Arbor. He obtained his PhD from Akita University School of Medicine, Akita, Japan (1992) and MD degree from Norman Bethune University Medical Science, ChangChun, China (1983). Dr Quan received his postdoctoral training at Wayne State University and University of Michigan in the Department of Dermatology (1997).
Research in Dr. Quan's laboratory studies the molecular mechanisms of skin aging and age-related diseases focusing on three major areas: matrix biology, cell-matrix interaction, and tumor microenvironment and skin cancer. His current efforts are focused on age-associated dermal microenvironment (AADM) impairs skin structure/function and creates a tissue microenvironment that promotes age-related skin diseases, like poor wound healing and development of skin cancer. Dr. Quan's laboratory is specifically interested in the biological functions of CCN1, a secreted, extracellular matrix-associated protein that regulates a broad range of cellular activities through direct binding to cell surface integrin receptors. Elevated CCN1 expression in aged human skin reduces collagen production and increased collagen fragmentation and alters expression of numerous other secreted proteins, which together have potential deleterious effects on the dermal microenvironment. Research in Dr. Quan's laboratory also studies collagen regulation and degradation focusing on TGF-ß/Smad signaling and MMPs.
Dr. Quan has published over 60 peer-reviewed papers and books as an editor. He has been awarded Nathan Shock Center for the Biology of Aging, American Dermatology Foundation, and NIH RO1 grants.