Manuela Grazina is specialized in Human Genetics, Biochemical Genetics and Pharmacogenomics, with a major focus in the study of a group of rare diseases, mitochondrial cytopathies, and neuropsychiatric disorders, particularly drug addiction and pain.
She has got her PhD in Biomedical Sciences in the area of Biochemical Genetics (2006), Graduated in Biomedicine (1997), Master in Cell Biology (specialization in Neurogenetics; 2004) and she has a degree in Biochemistry (5 years grade, pre – Bologna, 1991), at the University of Coimbra.
She is member of CNC as Researcher since 1992, and created the Laboratory of Biochemical Genetics (in CNC / FMUC) in 1995, at the University of Coimbra, with development of biochemical and genetic tests as tools for reverse translational research and diagnostics, with a strong component of Services to the community. She is the Head of the Laboratory of Biochemical Genetics, Center for Neuroscience of Coimbra, since March 1995.
She has established several international collaborations aiming to bring new developments to the research group, namely at the Baylor College of Medicine (Houston, USA), University of Newcastle upon Type (UK), Mitochondrial Biology Unit - Medical Research Council (Cambridge , UK) and CICAB Clinical Research Centre Extremadura University Hospital and Medical School, (Badajoz, Spain).
She has settled a study group of Pharmacogenomics Research in 2007, with the goal of identifying complete genetic and metabolic profiles influencing metabolism and toxicity of xenobiotics (eg drugs) and Manuela Grazina is a member of the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics (RIBEF) since February 2012.
Manuela Grazina coordinates a group of Reverse Translational Research in Mitochondrial Bigenomics and Pharmacogenomics, at the CNC, in close liaison with the Faculty of Medicine, University of Coimbra, since 2008.
She is an Assistant Professor at the Faculty of Medicine, University of Coimbra, where she has been teaching since 1996. Manuela Grazina is also teaching the discipline of Human Genetics in Universities of Évora (since 2010) and Algarve (since 2008), under the scope of cooperation between Universities, and collaborates in teaching with other Universities / Colleges (Faculties of Pharmacy of Lisbon and Coimbra, Institute of Biomedical Sciences Abel Salazar - Porto). Additionally, Manuela Grazina has been dedicated to the Certification of Quality and she is Director of Quality at CNC since 2006.
Manuela Grazina has a strong experience in organizing Advanced Courses (14, since 2010) and has also organized several scientific meetings, workshops and seminars.
She is the co -author of 32 "peer -reviewed" publications, including 4 book chapters and 74 abstracts published in proceedings of scientific meetings (majority indexed and peer-reviewed), as well as 380 scientific communications, 252 of which are posters , 48 conferences by invitation and 80 oral presentations.
Manuela Grazina is responsible for the supervision of 12 PhD theses (1 completed), 32 MSc (26 completed) and 20 monographs (all completed). She has been participating in 17 research funded projects, includes 2 (FCT), in which she is the Principal Investigator.