We are dissecting the cytokine network and determine which cells are producing or responding to a particular cytokine. One of our favourite molecule we are analysing is Interleukin-10. By inactivating the expression of Interleukin-10 in various cell types we can determine the importance of a particular cell type in a given immunological response. By this approach we could identify that T lymphocytes are the key cells producing Interleukin-10 and thereby control the Immune system of the gut. In addition, we now identified two critical target cells in the gut for Interleukin-10, T cells and macrophages. For the latter, Steffen Jung and me received the first Lord Alliance price in 2015.