The Brodsky Laboratory has been studying clathrin biochemistry, cell biology, and physiology for nearly 30 years. The group was based at the University of California, San Francisco (UCSF) until 2014, when Professor Brodsky accepted a position as Professor of Cell Biology and Director of the Division of Biosciences at University College London (UCL).
Frances Brodsky graduated from Harvard University with a degree in Biochemical Sciences in 1976, and earned her doctorate from Oxford University under a Marshall Scholarship in 1979. Brodsky's graduate work with immunologist Sir Walter Bodmer applied the then-novel technology of monoclonal antibodies to study human histocompatability molecules (HLA). Brodsky worked as a postdoctoral fellow, first with Jack Strominger at Harvard, and then with Peter Parham at Stanford University, where she discovered that the clathrin protein controls intracellular transport important for HLA stimulation of immune responses. Brodsky then joined Becton Dickinson Immunocytometry Systems as a Programme Manager, where she ran her own lab for four years before becoming an Assistant Professor at UCSF. Brodsky was awarded tenure in 1994, and was a full professor at UCSF until 2014, when she joined UCL. Prof. Brodsky has served as a member and chair of numerous boards, study sections, and advisory committees for organisations such as the U.S. National Institutes of Health and the Pew Scholars Program. In 2000, Brodsky co-founded the scientific journal Traffic, which specialises in intracellular transport, and now serves as Reviews Editor. Research in the Brodsky lab continues to focus on the biochemical and physiological functions of clathrin.