Following first class honours from the University of Cambridge, Nick Holliday carried out his PhD studies at King’s College London (awarded 1998), supported by a prize AJ Clark PhD studentship from the British Pharmacological Society. During subsequent postdoctoral work in London, his interests in peptide messengers regulating appetite and metabolism became focussed on molecular mechanisms underlying the signalling and regulation of their receptors. Dr. Holliday was awarded a competitive independent RCUK fellowship at the University of Nottingham in 2006, was appointed Lecturer in 2011 and Associate Professor of Pharmacology in 2013.
Dr. Holliday’s lab focuses on G protein coupled receptor kinetics, signalling and trafficking, especially related to arrestins, and on using novel imaging techniques to investigate the underlying mechanisms. On the basis of previous support from the MRC (G0700049), his group developed a novel fluorescence complementation assay to quantify receptor-beta-arrestin association by high content imaging methods, and to assess the molecular properties of these complexes using fluorescence correlation spectroscopy (FCS). This work has been recognised by the prize award of the 2011 Bill Bowman travelling lectureship from the British Pharmacological Society, together with a number of invited reviews. It has also continued to support high calibre international academic collaborations and funding (most recently a 4 year collaborative project grant with Dr Rafael Roesler funded by CAPES, Brazil), secure industrial funding (Mars, AZ, GSK), and consultancy (Excellerate Biosciences, Novo Nordisk). His group currently consists of 1 post doctoral research assistant and 7 PhD students.
Dr. Holliday has also been actively involved in public engagement, including an arts crossover project to explain the use of imaging in pharmacology (“Hijacking Natural Systems”), funded by the Wellcome Trust.