Jean-Francois Fonteneau

Country: France

Keywords: Cancer, antitumor immune response, immunogenic cell death, oncolytic virus, measles virus,T lymphocytes, dendritic cells, tumor antigens

Websites:
Centre de Recherche en Cancérologie Nantes-Angers (CRCNA)
INSERM UMR892 team4

Biography

I received the Ph.D. degree from Nantes University, France, in 1999. During my thesis training (1995-1999), I studied CD8+ T lymphocytes response against melanoma in the INSERM Laboratory of Pr Francine Jotereau, Nantes, France. I then joined Dr Nina Bhardwaj’s group in Dr Ralph Steinman Laboratory as a Postdoctoral Fellow at Rockefeller University, New York, USA, from 1999 to 2003, where I studied dendritic cells (DC) biology, notably cross-presentation of viral and tumor antigens and interactions between virus/myeloid DC/plasmacytoid DC. In 2003, I returned to Pr Francine Jotereau Laboratory, INSERM U892, Nantes to identify new melanoma epitopes recognized by patient’s CD8+ and CD4+ T cells. In 2009, I joined Dr Marc Gregoire's Laboratory, INSERM U892, Nantes, to study attenuated measles virus as an oncolytic virus for antitumor virotherapy of pleural mesothelioma to induce immunogenic cell death of tumor cells.

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