I am currently investigating covalently cross-linked dimers of amyloid beta (Aβ), a peptide highly associated with the neurodegenerative dementia- Alzheimer's disease (AD). This research project is designed to act as a model for the intrinsic link between AD clinical pathology and the SDS-stable Aβ dimer species which is apparent following biochemical analysis of AD brain. My overall focus is to determine structural elements required by a covalently cross-linked Aβ dimer to elicit a synaptotoxic effect, be it as an isolated dimer or as part of an aggregated species.

Record last modified Nov 6, 2018 11:35:22 PM