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medicinal chemistry, chemical biology, cancer, structure-based drug design, protein-protein interactions, covalent inhibitors, urokinase receptor, transcription factors, fragment-based drug design, RAS GTPase, Rho GTPase
United States

Activities

Employment (5)

University of Illinois Urbana-Champaign: Urbana, Illinois, US

2024-03-01 to present | Professor (Biochemistry)
Employment
Source: Self-asserted source
Samy O. Meroueh

Indiana University School of Medicine: Indianapolis, Indiana, US

2017 to 2024-02-29 | Professor (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Samy O. Meroueh

Indiana University School of Medicine: Indianapolis, IN, US

2006 to 2017 | Associate Professor (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Samy O. Meroueh

University of Notre Dame: Notre Dame, IN, US

2003 to 2006 | Postdoctoral Fellow (Chemistry and Biochemistry)
Employment
Source: Self-asserted source
Samy O. Meroueh

Wayne State University: Detroit, MI, US

2001-11 to 2003 | Postdoctoral Associate (Chemistry)
Employment
Source: Self-asserted source
Samy O. Meroueh

Education and qualifications (1)

Wayne State University: Detroit, MI, US

1995 to 2001 | PhD (Chemistry)
Education
Source: Self-asserted source
Samy O. Meroueh

Works (13)

Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction

RSC Medicinal Chemistry
2023 | Journal article
Contributors: Khuchtumur Bum-Erdene; Mona K. Ghozayel; Mark J. Zhang; Giovanni Gonzalez-Gutierrez; Samy O. Meroueh
Source: check_circle
Crossref

Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling

Biochemistry
2023-11-21 | Journal article
Contributors: Robert J. Brenner; Alexander D. Landgraf; Khuchtumur Bum-Erdene; Giovanni Gonzalez-Gutierrez; Samy O. Meroueh
Source: check_circle
Crossref

Exploring Covalent Bond Formation at Tyr‐82 for Inhibition of Ral GTPase Activation

ChemMedChem
2023-08-15 | Journal article
Contributors: Alexander D. Landgraf; I‐Ju Yeh; Mona K. Ghozayel; Khuchtumur Bum‐Erdene; Giovanni Gonzalez‐Gutierrez; Samy O. Meroueh
Source: check_circle
Crossref

Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors

ACS Chemical Neuroscience
2023-07-19 | Journal article
Contributors: Muhammad S. Hussain; Degang Liu; Warren J. Alilain; Samy O. Meroueh
Source: check_circle
Crossref

Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists

Journal of Medicinal Chemistry
2023-01-12 | Journal article
Contributors: Khuchtumur Bum-Erdene; I-Ju Yeh; Giovanni Gonzalez-Gutierrez; Mona K. Ghozayel; Karen Pollok; Samy O. Meroueh
Source: check_circle
Crossref

Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation

ChemMedChem
2022-03-18 | Journal article
Contributors: Khuchtumur Bum‐Erdene; Mona K. Ghozayel; David Xu; Samy O. Meroueh
Source: check_circle
Crossref

Small‐Molecule Inhibition of the uPAR ⋅ uPA Interaction by Conformational Selection

ChemMedChem
2021-01-19 | Journal article
Contributors: David Xu; Khuchtumur Bum‐Erdene; Julie M. Leth; Mona K. Ghozayel; Michael Ploug; Samy O. Meroueh
Source: check_circle
Crossref

Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR·uPA Interaction

ACS Medicinal Chemistry Letters
2021-01-14 | Journal article
Contributors: Khuchtumur Bum-Erdene; Degang Liu; David Xu; Mona K. Ghozayel; Samy O. Meroueh
Source: check_circle
Crossref

Chemical Space Overlap with Critical Protein–Protein Interface Residues in Commercial and Specialized Small‐Molecule Libraries

ChemMedChem
2019-01-08 | Journal article
Contributors: Yubing Si; David Xu; Khuchtumur Bum‐Erdene; Mona K. Ghozayel; Baocheng Yang; Paul A. Clemons; Samy O. Meroueh
Source: check_circle
Crossref

Mimicking Intermolecular Interactions of Tight Protein–Protein Complexes for Small‐Molecule Antagonists

ChemMedChem
2017-11-08 | Journal article
Contributors: David Xu; Khuchtumur Bum‐Erdene; Yubing Si; Donghui Zhou; Mona K. Ghozayel; Samy O. Meroueh
Source: check_circle
Crossref

A Computational Investigation of Small-Molecule Engagement of Hot Spots at Protein–Protein Interaction Interfaces

Journal of Chemical Information and Modeling
2017-09-25 | Journal article
Contributors: David Xu; Yubing Si; Samy O. Meroueh
Source: check_circle
Crossref

Structure‐Based Target‐Specific Screening Leads to Small‐Molecule CaMKII Inhibitors

ChemMedChem
2017-05-09 | Journal article
Contributors: David Xu; Liwei Li; Donghui Zhou; Degang Liu; Andy Hudmon; Samy O. Meroueh
Source: check_circle
Crossref

Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein–Protein Interaction

Biochemistry
2017-03-28 | Journal article
Contributors: Degang Liu; David Xu; Min Liu; William Eric Knabe; Cai Yuan; Donghui Zhou; Mingdong Huang; Samy O. Meroueh
Source: check_circle
Crossref

Peer review (36 reviews for 9 publications/grants)

Review activity for ACS biomaterials science & engineering. (1)
Review activity for ACS chemical biology. (1)
Review activity for ACS chemical neuroscience. (1)
Review activity for ACS medicinal chemistry letters. (2)
Review activity for ACS omega. (1)
Review activity for Biochemistry. (3)
Review activity for ChemMedChem. (3)
Review activity for Journal of chemical information and modeling. (7)
Review activity for Journal of medicinal chemistry. (17)