Following medical training in Germany and the U.K., Matthias Hentze did his postdoc at the NIH (USA) in the late eighties, when he and his colleagues discovered “iron-responsive elements” initiating his interests in posttranscriptional gene regulation (translation, mRNA stability, NMD, miRNAs) and diseases of iron metabolism (anemias, hemochromatosis, degenerative diseases). Recent work by the Hentze group has uncovered hundreds of new RNA-binding proteins, including many metabolic enzymes. Supported by an ERC Advanced Grant, their current work focuses on the elucidation of connections between metabolism and gene regulation.
Matthias Hentze co-founded and co-directs the "Molecular Medicine Partnership Unit", a joint interdisciplinary and translational research unit of the Medical Faculty of Heidelberg University and the EMBL, which bridges between medicine and molecular biology. Matthias Hentze’s research contributions have been recognized in numerous ways including Germany’s prestigious Gottfried Wilhelm Leibniz Prize in 2000, the 2007 Lautenschläger Research Prize of Heidelberg University, and the 2015 Feodor Lynen Medal of the German Society for Biochemistry and Molecular Biology. He is an elected member of the European Molecular Biology Organisation (EMBO), the German Academy of Sciences Leopoldina, and an Honorary Faculty Member of the Victor Chang Cardiac Research Institute in Sydney (Australia). He further serves in numerous international scientific advisory and editorial boards.