As the Clinical Core Director of the NIA-funded Boston University Alzheimer’s Disease Center (BU ADC), I oversee a multidisciplinary group of talented scientists and clinicians and direct the center’s longitudinal research registry, as well as several NIH- and industry-funded diagnostic, prevention, and treatment trials. The major focus of my current research is on the long-term effects of repetitive head impacts in athletes, including the neuropathological, genetic, neuroimaging, biomarker development, and clinical diagnosis and descriptions of the neurodegenerative disease, chronic traumatic encephalopathy (CTE). Other areas of my current and recent research program include the diagnosis, risk factors, and treatment of cognitive decline and neuropsychiatric dysfunction in aging. I have also published extensively on the psychometric properties of many widely used tests in neuropsychology, as well as the use of various instruments and biomarkers in the differential diagnosis of neurodegenerative disease. In addition, I have developed several commonly used tests and instruments, including the Neuropsychological Assessment Battery (NAB).