As an organic chemist, I am interested in the design and synthesis of innovative compounds for pharmaceutical applications. These chemicals can be either tools (like fluorescent or radiolabelled probes) beneficial to understand biological mechanisms or therapeutic agents exhibiting activities against major diseases such as cancer, Alzheimer, HIV.
My courses lend me a knowledgeable chemist in both organic and bioorganic / medicinal fields. My diverse employment allowed me to work in multidisciplinary environments covering industrial and academic research. Indeed, my HND internship at Sanofi-Aventis, my apprenticeship at Bayer Cropscience and my M.Sc internship in the ITAV (USR 3505) allowed me to discover industrial world and to develop librairies of therapeutic compounds with specific responses. My thesis in the ICN (UMR 7272) was in direct connection with the precise aspect of medicinal chemistry; that is the synthesis of fluorescent probes to study biological mechanisms as DNA methylation. My Ph.D was concluded by five publications, one submitted and two in progress. In brief, the years I have spent in this domain not only enriched my scientific skills but also enhanced my personal and communication potentials.
After my Ph.D defense, I was recruited as an Assistant Lecturer in the research group of Prof. Dr. Alain Burger (UMR 7272) for a one-year period where I pursued my Ph.D work on the synthesis of fluorescent probes to study DNA conformational changes.
I am currently working on the development of alkylated lysine derivatives targeting epigenetic proteins & enzymes associated with the Post-Transcriptional Modifications (PTMs) of histones, such as 'Erasers' (Sirtuins, HDACs, Lysine-specific histone demethylase 1 [LSD1]) and 'Readers' (Spindlin1) in the pharmaceutical research group of Prof. Dr. Manfred Jung.