I lead a structural biology research lab at the Department of Molecular Biology, Aarhus University, Denmark, focusing on the molecular mechanisms underlying RNA metabolism and decay in eukaryotic organisms.
In the lab we use molecular biology, biochemistry, and x-ray crystallography to study the structure and function of a number of important protein and RNA macromolecules involved in regulation and decay of RNA in both the nuclear and cytoplasmic compartments of the eukaryotic cell.
Research projects focus on several aspects of controlled 3'-5' degradation of mRNA via the nuclear exosome and cytoplasmic decay processes, such as deadenylation. We use both bacteria and yeast as model systems to study molecules which are widespread in nature, from the simplest living beings to man. You can read more about our research projects in the research section on the lab web page.
Our lab forms part of the Centre for Structural Biology (CSB), the largest structural biology facility in Denmark with more than 30 years of experience with structure determination of biological macromolecules.
Have a look at our lab home page: http://www.bioxray.au.dk/~deb
Specialties:X-ray crystallography, protein-nucleic acid interactions, biochemistry, RNA metabolism, RNA degradation