Alzheimer’s disease therapy: focus on synapses
Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular Aβ
Current theories for the molecular and cellular pathogenesis of Alzheimer's disease
Editorial - A Milestone for Current Alzheimer Research [Hot Topic: Neurogenesis Catalyst Conference (Guest Editors: Howard M. Fillit & Gunnar Gouras) ]
Intraneuronal Aß Accumulation, Amyloid Plaques, and Synapse Pathology in Alzheimers Disease
Molecular Pathology of Dementia
ADAM10 and BACE1 are localized to synaptic vesicles.
ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation.
β-Amyloid peptides and amyloid plaques in Alzheimer's disease.
Activity-independent release of the amyloid β-peptide from rat brain nerve terminals.
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.
Convergence of synapses, endosomes, and prions in the biology of neurodegenerative diseases.
Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.
The inside-out amyloid hypothesis and synapse pathology in Alzheimer's disease.
Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses.
mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease.
Pathology of synapses and dendritic spines.
Impaired β-amyloid secretion in Alzheimer's disease pathogenesis.
High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.
Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.
Analysis of vesicular trafficking in primary neurons by live imaging.
Coenzyme Q10 decreases amyloid pathology and improves behavior in a transgenic mouse model of Alzheimer's disease.
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.
Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease.
Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.
Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.
Immunotherapy for Alzheimer disease.
Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation.
Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.
Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Beta-amyloid modulation of synaptic transmission and plasticity.
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.
Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.
Neurogenesis as a therapeutic strategy for cognitive aging and Alzheimer's disease.
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.
Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response.
Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease.
Regulation of NMDA receptor trafficking by amyloid-beta.
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.
Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.
The immune system, amyloid-beta peptide, and Alzheimer's disease.
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.
Chaperones increase association of tau protein with microtubules.
Metal chelator decreases Alzheimer beta-amyloid plaques.
Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides.
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques.
Apolipoprotein E, A beta-amyloid, and the molecular pathology of Alzheimer's disease. Therapeutic implications.
Myotonia in colchicine myoneuropathy.
Mesencephalic clefts with associated eye movement disorders.
Tyrosine-hydroxylase-containing neurons in the primate basal forebrain magnocellular complex.