Assistant Professor, Department of Genetics, Washington University School of Medicine
Assistant Director, McDonnell Genome Institute, Washington University School of Medicine
My lab conducts research in medical genetics specializing in the application of molecular biology, informatics, and statistics to the study of cancer.
Cancer informatics - a combination of genomics, data analysis, and bioinformatics methods development with the ultimate goal of increasing our understanding of cancer biology and improving cancer treatment. I am one of a few scientists leading development of our clinical cancer sequencing and analysis pipeline, development of improved somatic event detection, evaluation of multiple tools and algorithms, and the application of these methods to several large scale next-generation sequencing projects involving: evolution of breast cancer under treatment, the genomic landscape of hepatocellular cancer, BRAF inhibitor resistance in colon cancer, clinical applications of next-generation sequencing in ALL, etc.