Born February 27, 1965, Spain
1983-1988 B.Sc. Biology. University of Navarra. Spain
1989-1992 Ph.D. Biology. “Severo Ochoa” Molecular Biology Center. Universidad Autónoma de Madrid, Spain.
1993 EMBO short term posdoctoral fellow. Max Planck Institut für Züchtungsforschung. Cologne. Germany
1994 Lecturer in Microbiology. Public University of Navarra. Spain
1995-1997 EU Postdoctoral fellow. Unité des interactions Bacteries-Celules. Institut Pasteur. France.
1998- 2008 Assistant Professor of Microbiology. Universidad Pública de Navarra
1999- Group leader “Laboratory of Microbial Biofilms”. Center for Agrobiotecnology. Public University of Navarra/CSIC. Spain
2006-2009 Deputy Director of the Center for Agrobiotechnology. Public University of Navarra/CSIC. Spain
2008- Professor of Microbiology. Public University of Navarra. Spain
2009-2010 Visiting scientist. Cold Spring Harbor Laboratory. USA
2015- Director of Navarrabiomed, Biomedical research center. Public Department of health-Public University of Navarra. Spain
Since establishing his own laboratory at the Public University of Navarra in 1998, Dr. Lasa participate in building the Institute of Agrobiotechnology, and more recently, 2015, he has moved to a new Biomedical Research Center, named Navarrabiomed. His laboratory has been interested on applying genetic approaches to study bacterial biofilms. Research in the “Laboratory of Microbial biofilms” Unit is centered on the genetic characterization of bacterial biofilm formation process and the role of biofilm development during infection. Our approach is aimed at three main topics: 1) regulatory process controlling biofilm development process, 2) signal transduction cascades that connect environmental conditions with biofilm development, in particular those involving c-di-GMP and two-component systems, and 3) role of biofilm during infection. Our goal is to decipher the regulatory networks involved in the biofilm development and the relevance of biofilm formation during bacterial infection.
The more relevant findings of Dr. Lasa’s laboratory have been: (i) the identification of family of proteins (Bap) able to built a proteinaceous biofilm matrix in the absence of exopolysaccharides; (ii) the characterization of role of the GGDEF family of proteins and c-di-GMP signal transduction network in Salmonella biofilm formation process, providing some of the earliest knowledge on the interchangeability between the different members of the GGDEF-domain proteins; (iii) the existence of a genome-wide process of overlapping sense/antisense RNA transcription that it is processed by the activity of double stranded endoribonuclease, RNase III.