Thomas Lufkin
0000-0002-7902-4771
Keywords: Regenerative medicine, embryonic stem cells, skeleton, genomics, transgenic, iPS cells, embryo, transcription, gene regulation, developmental biology
Websites:
Google Scholar
Clarkson University
ResearchGate
Other IDs:
Scopus Author ID: 7003692182
Personal Information
Biography
Our research is in the novel area of Developmental Genomics and Regenerative Medicine with a focus on the molecular mechanisms controlling vertebral column development and an emphasis on early embryogenesis and embryonic stem cell commitment to specific differentiation pathways.
Publications
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Advances in Stem Cell Therapies: Pluripotent Stem Cells / Book 2 2013
Sng, J. and Lufkin, T., Lenka, Nibedita, (2013). "Advances in Stem Cell Therapies", vol. 2, pp. 1-22 -
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In Vivo Epigenomic Profiling of Germ Cells Reveals Germ Cell Molecular Signatures: Developmental Cell 2013
Ng, J. H. and Kumar, V. and Muratani, M. and Kraus, P. and Yeo, J. C. and Yaw, L. P. and Xue, K. and Lufkin, T. and Prabhakar, S. and Ng, H. H., (2013). "In Vivo Epigenomic Profiling of Germ Cells Reveals Germ Cell Molecular Signatures", Developmental Cell, pp. In Press -
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Making sense of Dlx1 antisense RNA: Developmental Biology 2013
Kraus, P. and Sivakamasundari, V. and Lim, S. L. and Xing, X. and Lipovich, L. and Lufkin, T., (2013). "Making sense of Dlx1 antisense RNA", Developmental Biology, vol. 376, pp. 224–235 -
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Pax1-EGFP: New Wildtype And Mutant EGFP Mouse Lines For Molecular And Fate Mapping Studies: Genesis: J of Genetics and Development 2013
Sivakamasundari, V. and Kraus, P. and Jie, S. and Lufkin, T., (2013). "Pax1-EGFP: New Wildtype And Mutant EGFP Mouse Lines For Molecular And Fate Mapping Studies", Genesis: J of Genetics and Development, pp. In Press. -
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Stemming The Degeneration: IVD Stem Cells And Stem Cell Regenerative Therapy For Degenerative Disc Disease: Advances in Stem Cells 2013
Sivakamasundari, V. and Lufkin, T., (2013). "Stemming The Degeneration: IVD Stem Cells And Stem Cell Regenerative Therapy For Degenerative Disc Disease", Advances in Stem Cells, vol. Article ID 724547, pp. 1-22 -
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Bridging the Gap: Understanding Embryonic Interverterbal Disc Development 2012
V, S & Lufkin, T, 2012, 'Bridging the Gap: Understanding Embryonic Interverterbal Disc Development', Cell & Developmental Biology, vol. 01, no. 02. -
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Development of the “Three-step MACS”: a novel strategy for isolating rare cell populations in the absence of known cell surface markers from complex animal tissue: J Biomolecular Techniques 2012
Lee, M. Y. and Lufkin, T., (2012). "Development of the “Three-step MACS”: a novel strategy for isolating rare cell populations in the absence of known cell surface markers from complex animal tissue", J Biomolecular Techniques, pp. Early Access -
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Emerging Stem Cell Therapies: Treatment, Safety, and Biology 2012
Sng, J & Lufkin, T, 2012, 'Emerging Stem Cell Therapies: Treatment, Safety, and Biology', Stem Cells International, vol. 123, no. 17, pp. 2424-9. -
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Endogenous tagging of the murine transcription factor Sox5 with hemaglutinin for functional studies: Transgenic Research 2012
Lee, W.J. and Kraus, P. and Lufkin, T., (2012). "Endogenous tagging of the murine transcription factor Sox5 with hemaglutinin for functional studies", Transgenic Research, vol. 21, no. 2, pp. 293-301 -
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Filling the Silent Void: Genetic Therapies for Hearing Impairment 2012
Sng, J & Lufkin, T, 2012, 'Filling the Silent Void: Genetic Therapies for Hearing Impairment', Genetics Research International, vol. 23, no. 9, pp. 2151-9. -
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Mouse strain specific gene expression differences for Illumina microarray expression profiling in embryos: BMC Research Notes 2012
Kraus, P. and Xing, X. and Lim, S.L. and Fun, M.E. and Sivakamasundari, V. and Yap, S.P. and Lee, H. and Karuturi, R.K. and Lufkin, T., (2012). "Mouse strain specific gene expression differences for Illumina microarray expression profiling in embryos", BMC Research Notes -
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New Bapx1 Cre-EGFP mouse lines for lineage tracing and conditional knockout studies: Genesis 2012
Sivakamasundari, V. and Yun Chan, H. and Yun Chan, H. and Peng Yap, S. and Xing, X. and Kraus, P. and Lufkin, T., (2012). "New Bapx1 Cre-EGFP mouse lines for lineage tracing and conditional knockout studies", Genesis, vol. 50, no. 4, pp. 375-383 -
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Regulatory Genomics: Insights from the Zebrafish: Current Topics in Genetics 2012
Chatterjee, S. and Lufkin, T., (2012). "Regulatory Genomics: Insights from the Zebrafish", Current Topics in Genetics, vol. 5, pp. 1-10 In press -
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A genome wide combinatorial approach to elucidate cis-regulatory elements for vertebrate developmental control genes: BMC Developmental Biology 2011
Chatterjee, S. and Bourque, G. and Lufkin, T., (2011). "A genome wide combinatorial approach to elucidate cis-regulatory elements for vertebrate developmental control genes", BMC Developmental Biology, vol. 11, pp. 63 -
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Alternative Splicing in Self-Renewal of Embryonic Stem Cells 2011
Cheong, C & Lufkin, T, 2011, 'Alternative Splicing in Self-Renewal of Embryonic Stem Cells', Stem Cells International, vol. 29, no. 7, pp. 1410-8. -
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Building a Pluripotency Interaction Network for Embryonic Stem Cells: Embryonic Stem Cells - Basic Biology to Bioengineering 2011
Ng, P. M. L. and Lufkin, T., Kallos, M. S., (2011). "Building a Pluripotency Interaction Network for Embryonic Stem Cells", vol. 1, pp. 305-320 -
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Comparison of IRES and F2A-based locus-specific multicistronic expression in stable mouse lines: PLoS ONE 2011
Chan, H.Y. and Sivakamasundari, V. and Xing, X. and Kraus, P. and Yap, S.P. and Ng, P. and Lim, S.L. and Lufkin, T., (2011). "Comparison of IRES and F2A-based locus-specific multicistronic expression in stable mouse lines", PLoS ONE, vol. 6, no. 12 -
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Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes: BMC Developmental Biology 2011
Chatterjee, S. and Bourque, G. and Lufkin, T., (2011). "Conserved and non-conserved enhancers direct tissue specific transcription in ancient germ layer specific developmental control genes", BMC Developmental Biology, vol. 11 -
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Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala: Journal of Comparative Neurology 2011
Wang, B. and Lufkin, T. and Rubenstein, J.L.R., (2011). "Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala", Journal of Comparative Neurology, vol. 519, no. 12, pp. 2320-2334 -
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Embryonic Stem Cells: Protein-Interaction Networks: BioMolecular Concepts 2011
Ng, P. M. L. and Lufkin, T., (2011). "Embryonic Stem Cells: Protein-Interaction Networks", BioMolecular Concepts, vol. 2, no. 1-2, pp. 13-25 -
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Fishing for function: Zebrafish BAC transgenics for functional genomics: Molecular BioSystems 2011
Chatterjee, S. and Lufkin, T., (2011). "Fishing for function: Zebrafish BAC transgenics for functional genomics", Molecular BioSystems, vol. 7, no. 8, pp. 2345-2351 -
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Generation of mice with a novel conditional null allele of the Sox9 gene: Biotechnology Letters 2011
Yap, S.P. and Xing, X. and Kraus, P. and Sivakamasundari, V. and Chan, H.Y. and Lufkin, T., (2011). "Generation of mice with a novel conditional null allele of the Sox9 gene", Biotechnology Letters, vol. 33, no. 8, pp. 1551-1558 -
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In silico tandem affinity purification refines an Oct4 interaction list: Stem Cell Research and Therapy 2011
Cheong, C.Y. and Lon Ng, P.M. and Ponnampalam, R. and Tsai, H.-H. and Bourque, G. and Lufkin, T., (2011). "In silico tandem affinity purification refines an Oct4 interaction list", Stem Cell Research and Therapy, vol. 2, no. 3 -
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Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines: BMC Medical Genomics 2011
Lam, S.H. and Lee, S.G. and Lin, C.Y. and Thomsen, J.S. and Fu, P.Y. and Murthy, K.R. and Li, H. and Govindarajan, K.R. and Nick, L.C. and Bourque, G. and Gong, Z. and Lufkin, T. and Liu, E.T. and Mathavan, S., (2011). "Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines", BMC Medical Genomics, vol. 4 -
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Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and Hoxd4: PLoS ONE 2011
Phua, S.L.C. and Sivakamasundari, V. and Shao, Y. and Cai, X. and Zhang, L.-F. and Lufkin, T. and Featherstone, M., (2011). "Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and Hoxd4", PLoS ONE, vol. 6, no. 10 -
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A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity: Nature 2010
Chia, N.-Y. and Chan, Y.-S. and Feng, B. and Lu, X. and Orlov, Y.L. and Moreau, D. and Kumar, P. and Yang, L. and Jiang, J. and Lau, M.-S. and Huss, M. and Soh, B.-S. and Kraus, P. and Li, P. and Lufkin, T. and Lim, B. and Clarke, N.D. and Bard, F. and Ng, H.-H., (2010). "A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity", Nature, vol. 468, no. 7321, pp. 316-320 -
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A more cost effective and rapid high percentage germ-line transmitting chimeric mouse generation procedure via microinjection of 2-cell, 4-cell, and 8-cell embryos with ES and iPS cells: Genesis 2010
Kraus, P. and Leong, G. and Tan, V. and Xing, X. and Goh, J.W. and Yap, S.P. and Lufkin, T., (2010). "A more cost effective and rapid high percentage germ-line transmitting chimeric mouse generation procedure via microinjection of 2-cell, 4-cell, and 8-cell embryos with ES and iPS cells", Genesis, vol. 48, no. 6, pp. 394-399 -
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A symphony of inner ear developmental control genes 2010
Chatterjee, S, Kraus, P & Lufkin, T, 2010, 'A symphony of inner ear developmental control genes', BMC Genetics, vol. 11, no. 1, p. 68. -
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Deletion of the WD40 domain of LRRK2 in zebrafish causes parkinsonism-like loss of neurons and locomotive defect: PLoS Genetics 2010
Sheng, D. and Qu, D. and Kwok, K.H.H. and Ng, S.S. and Lim, A.Y.M. and Aw, S.S. and Lee, C.W.H. and Sung, W.K. and Tan, E.K. and Lufkin, T. and Jesuthasan, S. and Sinnakaruppan, M. and Liu, J., (2010). "Deletion of the WD40 domain of LRRK2 in zebrafish causes parkinsonism-like loss of neurons and locomotive defect", PLoS Genetics, vol. 6, no. 4 -
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Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons: Journal of Neuroscience 2010
Wang, Y. and Dye, C.A. and Sohal, V. and Long, J.E. and Estrada, R.C. and Roztocil, T. and Lufkin, T. and Deisseroth, K. and Baraban, S.C. and Rubenstein, J.L.R., (2010). "Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons", Journal of Neuroscience, vol. 30, no. 15, pp. 5334-5345 -
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Tbx3 improves the germ-line competency of induced pluripotent stem cells: Nature 2010
Han, J. and Yuan, P. and Yang, H. and Zhang, J. and Soh, B.S. and Li, P. and Lim, S.L. and Cao, S. and Tay, J. and Orlov, Y.L. and Lufkin, T. and Ng, H.-H. and Tam, W.-L. and Lim, B., (2010). "Tbx3 improves the germ-line competency of induced pluripotent stem cells", Nature, vol. 463, no. 7284, pp. 1096-1100 -
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The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells: Cell Stem Cell 2010
Heng, J.-C.D. and Feng, B. and Han, J. and Jiang, J. and Kraus, P. and Ng, J.-H. and Orlov, Y.L. and Huss, M. and Yang, L. and Lufkin, T. and Lim, B. and Ng, H.-H., (2010). "The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells", Cell Stem Cell, vol. 6, no. 2, pp. 167-174 -
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The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells: Cell Stem Cell 2010
Heng, J. C. and Feng, B. and Han, J. and Jiang, J. and Kraus, P. and Ng, J. H. and Orlov, Y. L. and Huss, M. and Yang, L. and Lufkin, T. and Lim, B. and Ng, H. H., (2010). "The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells", Cell Stem Cell, vol. 6, no. 2, pp. 167-74 -
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The role of post-transcriptional RNA processing and plasmid vector sequences on transient transgene expression in zebrafish: Transgenic Research 2010
Chatterjee, S. and Min, L. and Karuturi, R.K.M. and Lufkin, T., (2010). "The role of post-transcriptional RNA processing and plasmid vector sequences on transient transgene expression in zebrafish", Transgenic Research, vol. 19, no. 2, pp. 299-304 -
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Transcriptional repression in ES cells: Journal of Cellular Biochemistry 2010
Cheong, C.Y. and Lufkin, T., (2010). "Transcriptional repression in ES cells", Journal of Cellular Biochemistry, vol. 110, no. 2, pp. 288-293 -
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Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb: Nature Cell Biology 2009
Feng, B. and Jiang, J. and Kraus, P. and Ng, J.-H. and Heng, J.-C.D. and Chan, Y.-S. and Yaw, L.-P. and Zhang, W. and Loh, Y.-H. and Han, J. and Vega, V.B. and Cacheux-Rataboul, V. and Lim, B. and Lufkin, T. and Ng, H.-H., (2009). "Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb", Nature Cell Biology, vol. 11, no. 2, pp. 197-203 -
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Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs: Development 2008
Jeong, J. and Li, X. and McEvilly, R.J. and Rosenfeld, M.G. and Lufkin, T. and Rubenstein, J.L.R., (2008). "Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs", Development, vol. 135, no. 17, pp. 2905-2916 -
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MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1: Stem Cells 2008
Tay, Y.M.-S. and Tam, W.-L. and Ang, Y.-S. and Gaughwin, P.M. and Yang, H. and Wang, W. and Liu, R. and George, J. and Ng, H.-H. and Perera, R.J. and Lufkin, T. and Rigoutsos, I. and Thomson, A.M. and Lim, B., (2008). "MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1", Stem Cells, vol. 26, no. 1, pp. 17-29 -
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Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis: Developmental Dynamics 2007
Simon, R. and Lufkin, T. and Bergemann, A.D., (2007). "Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis", Developmental Dynamics, vol. 236, no. 10, pp. 2792-2799 -
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In Situ Hybridization of Whole-Mount Mouse Embryos with RNA Probes: Hybridization, Washes, and Histochemistry: Cold Spring Harb. Protoc. 2007
Lufkin, T., (2007). "In Situ Hybridization of Whole-Mount Mouse Embryos with RNA Probes: Hybridization, Washes, and Histochemistry", Cold Spring Harb. Protoc. -
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In Situ Hybridization of Whole-Mount Mouse Embryos with RNA Probes: Preparation of Embryos and Probes: Cold Spring Harb. Protoc. 2007
Lufkin, T., (2007). "In Situ Hybridization of Whole-Mount Mouse Embryos with RNA Probes: Preparation of Embryos and Probes", Cold Spring Harb. Protoc. -
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Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells: Journal of Biological Chemistry 2007
Wang, Z.-X. and Teh, C.H.-L. and Kueh, J.L.L. and Lufkin, T. and Robson, P. and Stanton, L.W., (2007). "Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells", Journal of Biological Chemistry, vol. 282, no. 17, pp. 12822-12830 -
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Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells: Stem Cells 2007
Wang, Z.-X. and Kueh, J.L.L. and Teh, C.H.-L. and Rossbach, M. and Lim, L. and Li, P. and Wong, K.-Y. and Lufkin, T. and Robson, P. and Stanton, L.W., (2007). "Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells", Stem Cells, vol. 25, no. 9, pp. 2173-2182 -
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Bapx1 homeobox gene gain-of-function mice show preaxial polydactyly and activated Shh signaling in the developing limb: Developmental Dynamics 2006
Tribioli, C. and Lufkin, T., (2006). "Bapx1 homeobox gene gain-of-function mice show preaxial polydactyly and activated Shh signaling in the developing limb", Developmental Dynamics, vol. 235, no. 9, pp. 2483-2492 -
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Dlx homeobox gene control of mammalian limb and craniofacial development: American Journal of Medical Genetics, Part A 2006
Kraus, P. and Lufkin, T., (2006). "Dlx homeobox gene control of mammalian limb and craniofacial development", American Journal of Medical Genetics, Part A, vol. 140, no. 13, pp. 1366-1374 -
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Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus: Genesis 2006
Robledo, R.F. and Lufkin, T., (2006). "Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus", Genesis, vol. 44, no. 9, pp. 425-437 -
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Long-term room temperature storage of high-quality embryonic stem cell genomic DNA extracted with a simple and rapid procedure: Journal of Biomolecular Techniques 2006
Tribioli, C. and Lufkin, T., (2006). "Long-term room temperature storage of high-quality embryonic stem cell genomic DNA extracted with a simple and rapid procedure", Journal of Biomolecular Techniques, vol. 17, no. 4, pp. 249-251 -
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Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1: Nature Cell Biology 2006
Zhang, J. and Tam, W.-L. and Tong, G.Q. and Wu, Q. and Chan, H.-Y. and Soh, B.-S. and Lou, Y. and Yang, J. and Ma, Y. and Chai, L. and Ng, H.-H. and Lufkin, T. and Robson, P. and Lim, B., (2006). "Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1", Nature Cell Biology, vol. 8, no. 10, pp. 1114-1123 -
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HoxGenes: Embryonic Development Sep-2005
Lufkin, T, 2005, 'HoxGenes: Embryonic Development', Encyclopedia of Life Sciences, John Wiley & Sons, Ltd, Chichester. -
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The easy part is making the knockout July-2005
Lufkin, T, 2005, 'The easy part is making the knockout', Developmental Dynamics, vol. 233, no. 3, pp. 1173-1174. -
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Genetic variation in bone growth patterns defines adult mouse bone fragility: Journal of Bone and Mineral Research 2005
Price, C. and Herman, B.C. and Lufkin, T. and Goldman, H.M. and Jepsen, K.J., (2005). "Genetic variation in bone growth patterns defines adult mouse bone fragility", Journal of Bone and Mineral Research, vol. 20, no. 11, pp. 1983-1991 -
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Hmx homeobox gene function in inner ear and nervous system cell-type specification and development: Experimental Cell Research 2005
Wang, W. and Lufkin, T., (2005). "Hmx homeobox gene function in inner ear and nervous system cell-type specification and development", Experimental Cell Research, vol. 306, no. 2, pp. 373-379 -
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Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction: Developmental Cell 2005
Basson, M.A. and Akbulut, S. and Watson-Johnson, J. and Simon, R. and Carroll, T.J. and Shakya, R. and Gross, I. and Martin, G.R. and Lufkin, T. and McMahon, A.P. and Wilson, P.D. and Costantini, F.D. and Mason, I.J. and Licht, J.D., (2005). "Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction", Developmental Cell, vol. 8, no. 2, pp. 229-239 -
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Transcriptome analysis of zebrafish embryogenesis using microarrays: PLoS Genetics 2005
Mathavan, S. and Lee, S.G.P. and Mak, A. and Miller, L.D. and Murthy, K.R.K. and Govindarajan, K.R. and Tong, Y. and Wu, Y.L. and Lam, S.H. and Yang, H. and Ruan, Y. and Korzh, V. and Gong, Z. and Liu, E.T. and Lufkin, T., (2005). "Transcriptome analysis of zebrafish embryogenesis using microarrays", PLoS Genetics, vol. 1, no. 2, pp. 0260-0276 -
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Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx: Developmental Cell 2004
Wang, W. and Grimmer, J.F. and Van De Water, T.R. and Lufkin, T., (2004). "Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx", Developmental Cell, vol. 7, no. 3, pp. 439-453 -
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Expression of Tfap2d, the gene encoding the transcription factor Ap-2δ during mouse embryogenesis: Gene Expression Patterns 2003
Zhao, F. and Lufkin, T. and Gelb, B.D., (2003). "Expression of Tfap2d, the gene encoding the transcription factor Ap-2δ during mouse embryogenesis", Gene Expression Patterns, vol. 3, no. 2, pp. 213-217 -
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Murine homeobox gene control of embryonic patterning and organogenesis: Advances in Developmental Biology And Biochemistry 2003
Lufkin, T., (2003). "Murine homeobox gene control of embryonic patterning and organogenesis", vol. 13, pp. 276 -
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Postnatal Lethality in Mice Lacking the Sax2 Homeobox Gene Homologous to Drosophila S59/slouch: Evidence for Positive and Negative Autoregulation: Molecular and Cellular Biology 2003
Simon, R. and Lufkin, T., (2003). "Postnatal Lethality in Mice Lacking the Sax2 Homeobox Gene Homologous to Drosophila S59/slouch: Evidence for Positive and Negative Autoregulation", Molecular and Cellular Biology, vol. 23, no. 24, pp. 9046-9060 -
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Specification of jaw subdivisions by Dlx genes: Science 2002
Depew, M.J. and Lufkin, T. and Rubenstein, J.L.R., (2002). "Specification of jaw subdivisions by Dlx genes", Science, vol. 298, no. 5592, pp. 381-385 -
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The D1x5 and D1x6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development: Genes and Development 2002
Robledo, R.F. and Rajan, L. and Li, X. and Lufkin, T., (2002). "The D1x5 and D1x6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development", Genes and Development, vol. 16, no. 9, pp. 1089-1101 -
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The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis: Mechanisms of Development 2002
Tribioli, C. and Robledo, R.F. and Lufkin, T., (2002). "The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis", Mechanisms of Development, vol. 118, no. 1-2, pp. 161-163 -
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Hmx2 homeobox gene control of murine vestibular morphogenesis: Development 2001
Wang, W. and Chan, E.K. and Baron, S. and Van De Water, T. and Lufkin, T., (2001). "Hmx2 homeobox gene control of murine vestibular morphogenesis", Development, vol. 128, no. 24, pp. 5017-5029 -
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The Murine Otp Homeobox Gene Plays an Essential Role in the Specification of Neuronal Cell Lineages in the Developing Hypothalamus Nov-2000
Wang, W & Lufkin, T, 2000, 'The Murine Otp Homeobox Gene Plays an Essential Role in the Specification of Neuronal Cell Lineages in the Developing Hypothalamus', Developmental Biology, vol. 202, no. 2, pp. 354-449. -
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Mapping and Developmental Expression Analysis of the WD-Repeat Gene Preb Feb-2000
Taylor Clelland, C, Craciun, L, Bancroft, C & Lufkin, T, 2000, 'Mapping and Developmental Expression Analysis of the WD-Repeat Gene Preb', Genomics, vol. 14, no. 3, pp. 284-399. -
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Cre recombinase expression in the floorplate, notochord and gut epithelium in transgenic embryos driven by the Hoxa-1 enhancer III: Genesis 2000
Li, X. and Lufkin, T., (2000). "Cre recombinase expression in the floorplate, notochord and gut epithelium in transgenic embryos driven by the Hoxa-1 enhancer III", Genesis, vol. 26, no. 2, pp. 121-122 -
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Developmental Control by Hox Transcriptional Regulators and their Cofactors: Transcription Factors 2000
Lufkin, T., Locker, J., (2000). "Developmental Control by Hox Transcriptional Regulators and their Cofactors", pp. 215-235 -
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Hmx: An evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila: Mechanisms of Development 2000
Wang, W. and Lo, P. and Frasch, M. and Lufkin, T., (2000). "Hmx: An evolutionary conserved homeobox gene family expressed in the developing nervous system in mice and Drosophila", Mechanisms of Development, vol. 99, no. 1-2, pp. 123-137 -
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The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus: Developmental Biology 2000
Wang, W. and Lufkin, T., (2000). "The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus", Developmental Biology, vol. 227, no. 2, pp. 432-449 -
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Mammalian DIx homeobox gene control of craniofacial and inner ear morphogenesis: Journal of Cellular Biochemistry 1999
Kraus, P. and Lufkin, T., (1999). "Mammalian DIx homeobox gene control of craniofacial and inner ear morphogenesis", Journal of Cellular Biochemistry, vol. 76, no. SUPPL. 32/33, pp. 133-140 -
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The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen: Development 1999
Tribioli, C. and Lufkin, T., (1999). "The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen", Development, vol. 126, no. 24, pp. 5699-5711 -
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Chapter 2: Functional Architecture of Nervous Systems, Section II. Cellular and Molecular Neuroscience: Fundamental Neuroscience. 1998
Swanson, L. and Lufkin, T. and Colman, D., Bloom, F. E., (1998). "Chapter 2: Functional Architecture of Nervous Systems, Section II. Cellular and Molecular Neuroscience", pp. 7-35 -
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Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene: Development 1998
Wang, W. and Van De Water, T. and Lufkin, T., (1998). "Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene", Development, vol. 125, no. 4, pp. 621-634 -
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Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe Dec-1997
Tribioli, C & Lufkin, T, 1997, 'Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe', Gene, vol. 58, no. 2, pp. 203-233. -
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Assignment of the murine Hmx1 homeobox gene to the proximal region of mouse Chromosome 5 Nov-1997
Wang, W, Yoshiura, K, Murray, J & Lufkin, T, 1997, 'Assignment of the murine Hmx1 homeobox gene to the proximal region of mouse Chromosome 5', Mammalian Genome, vol. 52, no. 11, pp. 371-870. -
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Assignment of the murine Hmx2 and Hmx3 homeobox genes to the distal region of mouse chromosome 7: Chromosome Research 1997
Wang, W. and Lufkin, T., (1997). "Assignment of the murine Hmx2 and Hmx3 homeobox genes to the distal region of mouse chromosome 7", Chromosome Research, vol. 5, no. 7, pp. 501-502 -
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Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton: Mechanisms of Development 1997
Tribioli, C. and Frasch, M. and Lufkin, T., (1997). "Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton", Mechanisms of Development, vol. 65, no. 1-2, pp. 145-62 -
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Dicistronic LacZ and alkaline phosphatase reporter constructs permit simultaneous histological analysis of expression from multiple transgenes: BioTechniques 1997
Li, X. and Wang, W. and Lufkin, T., (1997). "Dicistronic LacZ and alkaline phosphatase reporter constructs permit simultaneous histological analysis of expression from multiple transgenes", BioTechniques, vol. 23, no. 5, pp. 874-882 -
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Linkage mapping of Sax2 to mouse Chromosome 5: Mammalian Genome 1997
Chen, X. and Lufkin, T., (1997). "Linkage mapping of Sax2 to mouse Chromosome 5", Mammalian Genome, vol. 8, no. 9, pp. 697-698 -
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Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos: Mechanisms of Development 1997
Nikolova, M. and Chen, X. and Lufkin, T., (1997). "Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos", Mechanisms of Development, vol. 69, no. 1-2, pp. 215-218 -
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OTP maps to mouse Chromosome 13: Mammalian Genome 1997
Wang, W. and Lufkin, T., (1997). "OTP maps to mouse Chromosome 13", Mammalian Genome, vol. 8, no. 7, pp. 537-538 -
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Transcriptional regulation of vertebrate Hox genes during embryogenesis: Critical Reviews in Eukaryotic Gene Expression 1997
Lufkin, T., (1997). "Transcriptional regulation of vertebrate Hox genes during embryogenesis", Critical Reviews in Eukaryotic Gene Expression, vol. 7, no. 3, pp. 195-213 -
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Dlx5 and Dlx6: An evolutionary conserved pair of murine homeobox genes expressed in the embryonic skeleton: Annals of the New York Academy of Sciences 1996
Chen, X. and Li, X. and Wang, W. and Lufkin, T., (1996). "Dlx5 and Dlx6: An evolutionary conserved pair of murine homeobox genes expressed in the embryonic skeleton", Annals of the New York Academy of Sciences, vol. 785, pp. 38-47 -
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Msx3: A novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system: Mechanisms of Development 1996
Wang, W. and Chen, X. and Xu, H. and Lufkin, T., (1996). "Msx3: A novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system", Mechanisms of Development, vol. 58, no. 1-2, pp. 203-215 -
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Transcriptional control of Hox genes in the vertebrate nervous system: Current Opinion in Genetics and Development 1996
Lufkin, T., (1996). "Transcriptional control of Hox genes in the vertebrate nervous system", Current Opinion in Genetics and Development, vol. 6, no. 5, pp. 575-580 -
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Chapter 5: Gene targeting in mammalian development and physiology: Gene Targeting 1995
Lufkin, T., Vega, M., (1995). "Chapter 5: Gene targeting in mammalian development and physiology", pp. 123-147 -
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Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila: Development 1995
Frasch, M. and Chen, X. and Lufkin, T., (1995). "Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila", Development, vol. 121, no. 4, pp. 957-974 -
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Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal: Development 1995
Lampron, C. and Rochette-Egly, C. and Gorry, P. and Dolle, P. and Mark, M. and Lufkin, T. and LeMeur, M. and Chambon, P., (1995). "Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal", Development, vol. 121, no. 2, pp. 539-548 -
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Targeted disruption of retinoic acid receptor α (RARα and RARγ results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism: Molecular and Cellular Biology 1995
Boylan, J.F. and Lufkin, T. and Achkar, C.C. and Taneja, R. and Chambon, P. and Gudas, L.J., (1995). "Targeted disruption of retinoic acid receptor α (RARα and RARγ results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism", Molecular and Cellular Biology, vol. 15, no. 2, pp. 843-851 -
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Function of the retinoic acid receptors (RARs) during development. (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants: Development 1994
Mendelsohn, C. and Lohnes, D. and Decimo, D. and Lufkin, T. and LeMeur, M. and Chambon, P. and Mark, M., (1994). "Function of the retinoic acid receptors (RARs) during development. (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants", Development, vol. 120, no. 10, pp. 2749-2771 -
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The cellular retinoic acid binding protein I is dispensable: Proceedings of the National Academy of Sciences of the United States of America 1994
Gorry, P. and Lufkin, T. and Dierich, A. and Rochette-Egly, C. and Décimo, D. and Dollé, P. and Mark, M. and Durand, B. and Chambon, P., (1994). "The cellular retinoic acid binding protein I is dispensable", Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 19, pp. 9032-9036 -
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High postnatal lethality and testis degeneration in retinoic acid receptor α mutant mice: Proceedings of the National Academy of Sciences of the United States of America 1993
Lufkin, T. and Lohnes, D. and Mark, M. and Dierich, A. and Gorry, P. and Gaub, M.-P. and LeMeur, M. and Chambon, P., (1993). "High postnatal lethality and testis degeneration in retinoic acid receptor α mutant mice", Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 15, pp. 7225-7229 -
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Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos: Proceedings of the National Academy of Sciences of the United States of America 1993
Dolle, P. and Lufkin, T. and Krumlauf, R. and Mark, M. and Duboule, D. and Chambon, P., (1993). "Local alterations of Krox-20 and Hox gene expression in the hindbrain suggest lack of rhombomeres 4 and 5 in homozygote null Hoxa-1 (Hox-1.6) mutant embryos", Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 16, pp. 7666-7670 -
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Roles of Hox genes: What we have learnt from gain of function and loss of function mutations in the mouse: Comptes Rendus de l'Academie des Sciences - Series III 1993
Mark, M. and Lufkin, T. and Dolle, P. and Dierich, A. and LeMeur, M. and Chambon, P., (1993). "Roles of Hox genes: What we have learnt from gain of function and loss of function mutations in the mouse", Comptes Rendus de l'Academie des Sciences - Series III, vol. 316, no. 9, pp. 995-1008 -
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Two rhombomeres are altered in Hoxa-1 mutant mice: Development 1993
Mark, M. and Lufkin, T. and Vonesch, J.-L. and Ruberte, E. and Olivo, J.-C. and Dolle, P. and Gorry, P. and Lumsden, A. and Chambon, P., (1993). "Two rhombomeres are altered in Hoxa-1 mutant mice", Development, vol. 119, no. 2, pp. 319-338 -
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Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene: Nature 1992
Lufkin, T. and Mark, M. and Hart, C.P. and Dollé, P. and LeMeur, M. and Chambon, P., (1992). "Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene", Nature, vol. 359, no. 6398 -
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Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene: Nature 1992
Lufkin, T. and Mark, M. and Hart, C.P. and Dolle, P. and LeMeur, M. and Chambon, P., (1992). "Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene", Nature, vol. 359, no. 6398, pp. 835-841 -
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Inactivation du gene Hox-1.6 chez la souris: vers le decodage des reseaux d'homeogenes de mammiferes: Medecines/Sciences 1992
Mark, M. and Lufkin, T. and Dierich, A. and LeMeur, M. and Chambon, P., (1992). "Inactivation du gene Hox-1.6 chez la souris: vers le decodage des reseaux d'homeogenes de mammiferes", Medecines/Sciences, vol. 8, pp. 334-339 -
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Retinoid receptors and binding proteins: Journal of Cell Science 1992
Lohnes, D. and Dierich, A. and Ghyselinck, N. and Kastner, P. and Lampron, C. and LeMeur, M. and Lufkin, T. and Mendelsohn, C. and Nakshatri, H. and Chambon, P., (1992). "Retinoid receptors and binding proteins", Journal of Cell Science, vol. 103, no. SUPPL. 16, pp. 69-76 -
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Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression: Cell 1991
Lufkin, T. and Dierich, A. and LeMeur, M. and Mark, M. and Chambon, P., (1991). "Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression", Cell, vol. 66, no. 6, pp. 1105-1119 -
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Proximal rat prolactin promoter sequences direct optimal, pituitary cell-specific transcription: Molecular Endocrinology 1989
Lufkin, T. and Jackson, A.E. and Pan, W.T. and Bancroft, C., (1989). "Proximal rat prolactin promoter sequences direct optimal, pituitary cell-specific transcription", Molecular Endocrinology, vol. 3, no. 3, pp. 559-566 -
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Identification by cell fusion of gene sequences that interact with positive trans-acting factors: Science 1987
Lufkin, T. and Bancroft, C., (1987). "Identification by cell fusion of gene sequences that interact with positive trans-acting factors", Science, vol. 237, no. 4812, pp. 283-286 -
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Productive infection of cultured human lymphoid cells by adenovirus: Journal of Virology 1987
Lavery, D. and Fu, S.M. and Lufkin, T. and Chen-Kiang, S., (1987). "Productive infection of cultured human lymphoid cells by adenovirus", Journal of Virology, vol. 61, no. 5, pp. 1466-1472 -
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RNA dot and blot hybridization: Selected procedures for endocrine and neuroendocrine studies: Methods in Enzymology 1986
White, B.A. and Lufkin, T. and Preston, G.M. and Bancroft, C., (1986). "RNA dot and blot hybridization: Selected procedures for endocrine and neuroendocrine studies", Methods in Enzymology, vol. VOL. 124, pp. 269-278 -
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Detection of two chromatin proteins which bind specifically to the 5'-flanking region of the rat prolactin gene: Molecular and Cellular Biology 1985
White, B.A. and Preston, G.M. and Lufkin, T.C. and Bancroft, C., (1985). "Detection of two chromatin proteins which bind specifically to the 5'-flanking region of the rat prolactin gene", Molecular and Cellular Biology, vol. 5, no. 11, pp. 2967-2974 -
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Mapping and Developmental Expression Analysis of the WD-Repeat Gene Preb
Taylor Clelland, C, Craciun, L, Bancroft, C & Lufkin, T, 2000, 'Mapping and Developmental Expression Analysis of the WD-Repeat Gene Preb', vol. 63, no. 3, pp. 391-399. -
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The Sound of Silence: Mouse Models for Hearing Loss
Chatterjee, S & Lufkin, T, 2011, 'The Sound of Silence: Mouse Models for Hearing Loss', vol. 2011, pp. 1-9.
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