Professor Wayne A. Phillips is a cellular and molecular biologist with a long-standing interest in the role of the phosphoinositide 3-kinase signalling pathway in cancer. His laboratory was one of the first to identify somatic mutations in the phosphoinositide 3-kinase family genes in human tumours and now studies the biological consequences and clinical significance of these mutations. Currently his work is focussed on using a novel Pik3ca knock-in mouse model to investigate the role, function, and mechanism of action of Pik3ca mutations in a physiologically relevant context in a number of different tumour types.
Prof. Phillips’ laboratory also has a major interest in the pathogenesis of Barrett’s oesophagus and is developing novel patient-derived xenografts and pre-clinical models with which to explore cellular and molecular mechanisms underlying development of Barrett’s metaplasia and its progression oesophageal adenocarcinoma. He is also using genomic approaches to understand the genetics of familial Barrett’s oesophagus.
Prof. Phillips obtained his Ph.D. from the University of Melbourne in 1983. Following postdoctoral positions in Germany and the United States, he returned to Australia as the DW Keir Research Fellow at the Royal Melbourne Hospital. He is currently a Senior Principal Research Fellow and Head of the Surgical Oncology Research Laboratory at the Peter MacCallum Cancer Centre in Melbourne and is a Professorial Fellow in both the Sir Peter MacCallum Department of Oncology, and the Department of Surgery (SVH), at the University of Melbourne. He is the Chair of the Breast Cancer Campaign (UK) Tissue Bank Advisory Council and a member of the Access Committee for the Victorian Cancer Biobank (Melbourne). He is also a member of the Peter MacCallum Cancer Centre Ethics Committee