Since 1991 I have been participating in routine necropsy and diagnostic histopathology of production animals. From 2001 and onwards I have been head of histopathology lab including the TSE confirmatory testing (histopathology and immunohistochemistry) in Denmark. From the beginning of 2013 I have furthermore been in charge of pet, fur and zoo animals as well as wildlife gross and histopathology. Besides pathologic anatomy and histopathology my routine diagnostic portfolio includes in situ identification of a few viruses and a long range of bacteria among other Fransciella tularensis, Coxiella burnetii (both notifiable pathogens), Mycoplasma spp., and Brachyspira spp. For more than 15 years FISH has been the cornerstone for development and implementation of new in situ methods and today DTU-VET is probably among the top five laboratories in the world within this topic.
In addition, my diagnostic responsibilities include case reporting as well as professional supervision and assistance to veterinarians and relevant authorities. The latter includes being a part of the contingency plan of the institute and e.g. the authorship of the annual report to the EU Commission “Laboratory Examinations of Transmissible Spongiform Encephalapathies in Denmark”.
In brief, my research has focused on 1) diseases in pigs with special reference to intestinal infections caused by Lawsonia intracellularis and spirochaetes of the genus Brachyspira in experimentally as well as in naturally infected animals. 2) development of specific in situ detection methods for identification of bacterial pathogens in experimentally as well as in naturally infected animals. 3) studying the pathogenesis of the skin disease bovine digital dermatitis with special emphasis on identification of Treponema spp., and other possibly causal bacteria. Recent research activities have focused on identification of bacteria in reproduction disorders in dairy cows and sows.