I am a reproduction biologist specialized in sperm cell and oocyte development. My research is centered on both basic and clinical aspects of gametogenesis, and on their influence on fertility.
It is my scientific objective to understand the fundamental biological properties of male and female reproductive cells, and to use that knowledge for the improvement of human reproductive health.
I- Spermatogenesis research:
Thematic area: (Epi)genetic regulation of male germ cell function.
I have previously reported the first association between DNA methylation defects in a germ line gene and abnormal human spermatogenesis (Navarro-Costa et al., 2010a). I also have extensive expertise on the clinical genetics of male infertility, particularly in the context of Y chromosome deletions (Navarro-Costa et al., 2010b and Navarro-Costa, 2012; among others). Such expertise is the basis of my role as assessor for the European Molecular Genetics Quality Network best practice program for the genetic diagnosis of male infertility.
II- Oogenesis research:
Thematic area: Molecular control of oocyte quality.
Using the Drosophila melanogaster model organism, I have uncovered an epigenetic program responsible for the temporal regulation of female meiotic transcription (Navarro-Costa et al., 2016). Recently, I have identified an oogenesis protein responsible for the assembly of the embryo genome after fertilisation [Prudêncio, (…) and Navarro-Costa, 2018].