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Works (11)

Hypercholesterolemia-induced LXR signaling in smooth muscle cells contributes to vascular lesion remodeling and visceral function

Proceedings of the National Academy of Sciences
2025-03-11 | Journal article
DOI: 10.1073/pnas.2417512122
Contributors: Hanming Zhang; Diego Sáenz de Urturi; Pablo Fernández-Tussy; Yan Huang; Daniel G. Jovin; Xinbo Zhang; Shushu Huang; Monkol Lek; Jonatas da Silva Catarino; Magdalena Sternak et al.
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DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time

2024-03-28 | Preprint
DOI: 10.7554/eLife.95627
Contributors: Sona Relovska; Huafeng Wang; Xinbo Zhang; Pablo Fernández-Tussy; Kyung Jo Jeong; Jungmin Choi; Yajaira Suárez; Jeffrey G. McDonald; Carlos Fernández-Hernando; Jean-Ju Chung
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DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time

2024-03-28 | Preprint
DOI: 10.7554/eLife.95627.1
Contributors: Sona Relovska; Huafeng Wang; Xinbo Zhang; Pablo Fernández-Tussy; Kyung Jo Jeong; Jungmin Choi; Yajaira Suárez; Jeffrey G. McDonald; Carlos Fernández-Hernando; Jean-Ju Chung
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DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time

2023-12-22 | Preprint
DOI: 10.1101/2023.12.21.572851
Contributors: Sona Relovska; Huafeng Wang; Xinbo Zhang; Pablo Fernández-Tussy; Kyung Jo Jeong; Jungmin Choi; Yajaira Suárez; Jeffrey G. McDonald; Carlos Fernández-Hernando; Jean-Ju Chung
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Genetic or therapeutic neutralization of ALK1 reduces LDL transcytosis and atherosclerosis in mice

Nature Cardiovascular Research
2023-05-11 | Journal article
DOI: 10.1038/s44161-023-00266-2
Contributors: Sungwoon Lee; Hubertus Schleer; Hyojin Park; Erika Jang; Michael Boyer; Bo Tao; Ana Gamez-Mendez; Abhishek Singh; Ewa Folta-Stogniew; Xinbo Zhang et al.
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Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis

Proceedings of the National Academy of Sciences
2021-11-23 | Journal article
DOI: 10.1073/pnas.2107682118
Contributors: Xinbo Zhang; Jeffrey G. McDonald; Binod Aryal; Alberto Canfrán‐Duque; Emily L. Goldberg; Elisa Araldi; Wen Ding; Yuhua Fan; Bonne M. Thompson; Abhishek K. Singh et al.
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Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice

Journal of Clinical Investigation
2021-09-01 | Journal article
DOI: 10.1172/JCI140989
Contributors: Abhishek K. Singh; Balkrishna Chaube; Xinbo Zhang; Jonathan Sun; Kathryn M. Citrin; Alberto Canfrán-Duque; Binod Aryal; Noemi Rotllan; Luis Varela; Richard G. Lee et al.
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Deficiency of histone lysine methyltransferase SETDB2 in hematopoietic cells promotes vascular inflammation and accelerates atherosclerosis

JCI Insight
2021-06-22 | Journal article
DOI: 10.1172/jci.insight.147984
Contributors: Xinbo Zhang; Jonathan Sun; Alberto Canfrán-Duque; Binod Aryal; George Tellides; Ying Ju Chang; Yajaira Suárez; Timothy F. Osborne; Carlos Fernández-Hernando
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Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis

Proceedings of the National Academy of Sciences
2021-02-02 | Journal article
DOI: 10.1073/pnas.2006478118
Contributors: Nathan L. Price; Xinbo Zhang; Pablo Fernández-Tussy; Abhishek K. Singh; Sean A. Burnap; Noemi Rotllan; Leigh Goedeke; Jonathan Sun; Alberto Canfrán-Duque; Binod Aryal et al.
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Targeted suppression of microRNA-33 in lesional macrophages using pH low-insertion peptides (pHLIP) improves atherosclerotic plaque regression

2020-10-29 | Other
DOI: 10.21203/rs.3.rs-92252/v1
Contributors: Xinbo Zhang; Noemi Rotllan; Alberto Canfrán-Duque; Jakub Toczek; Anna Moshnikova; Shipra Malik; Nathan Price; Elisa Araldi; Wen Zhong; Mehran Sadeghi et al.
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Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling

JCI Insight
2020-02-13 | Journal article
DOI: 10.1172/jci.insight.131384
Contributors: Han Zhou; Sameet Mehta; Swayam Prakash Srivastava; Kariona Grabinska; Xinbo Zhang; Chris Wong; Ahmad Hedayat; Paola Perrotta; Carlos Fernández-Hernando; William C. Sessa et al.
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