I am an Honorary Senior Lecturer and Principal Investigator in the University College London Institute of Neurology Department of Molecular Neuroscience. I am Honorary Consultant Neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London, where I run an autoimmune encephalitis and neuroimmunology clinic and monthly encephalitis clinical and academic meeting. I work on central nervous system neuroimmunological diseases, particularly autoimmune encephalitides (eg. associated with NMDAR, LGI1 or related autoantibodies), with a broader research interest in all neuroimmunology, neuropsychiatric involvement in SLE and relate conditions, and the role of inflammation in neurodegenerative disease and in neuropsychiatric disease. I have MRC and UCLH/UCL NIHR BRC support, and previous support from the Stanley Medical Research Institute. I am principal investigator on research studies related to the study of autoimmunity in neurological disease at UCL in collaboration with Dr Michael Lunn and Professor Emma Morris, with support from the NIHR UCLH BRC, and an MRC funded randomised controlled trial for individuals with psychosis and autoantibodies in the absence of definite encephalitis (SINAPPS2, run through the Leonard Wolfson Experimental Neurology Centre). We are working on understanding autoimmune encephalitis through a programme of basic science and translational research, including clinical trials, and in the development of clinical biomarkers in autoimmune encephalitis to speed up diagnosis and aid clinical management.
I trained in medicine at Clare College, Cambridge, with an elective period as externe in neurology at the Salpêtrière, Paris with Bertrand Fontaine. I trained in neurology with an East Anglian Neuroscience Training Fellowship in Cambridge, Norwich and the National Hospital for Neurology and Neurosurgery in London. I have a PhD in neuroimmunology (Cambridge), with time spent in the laboratories or clinics of Alasdair Coles, David Jayne (SLE), Seth Grant with Alex Bayes (Sanger), and Angela Vincent FRS (Oxford Weatherall Institute of Molecular Medicine).
Collaborators on funded projects include Profs Emma Morris, Judith Breuer, Dr Sofia Morfopoulou, Dr Tehmina Bharucha, Dr Julianne Brown, Profs Henrik Zetterberg, Henry Houlden and Jon Schott, Dr Michael Lunn, Dr Melanie Hart, the SINAPPS study group (Profs Alasdair Coles, Belinda Lennox, Peter Jones, Dr Thomas Kabir (McPin Foundation), London Research Associate Rebecca Pollard), MSc Students Ayesha Khatun and David Robaldo, honorary neurology specialist registrar Dr Rachel Brown, Dr Ava Easton and the Encephalitis Society https://www.encephalitis.info/