Brian Bigger graduated from Bath University in the UK with a degree in Applied Biology and later a PhD in mitochondrial gene therapy from Imperial College London, with Professor Charles Coutelle. After a further 4 years in London developing a stem cell gene therapy approach for haemophilia B in collaboration with Professor Dominique Bonnet at Cancer Research UK, he subsequently worked on haematopoietic stem cell migration at the National Blood Service and Oxford University also in the UK. In 2006, he moved to Manchester (UK), to set up the Stem Cell & Neurotherapies group at the University of Manchester in collaboration with Dr Rob Wynn, the director of the Blood and Marrow Transplant Unit at the Royal Manchester Children’s Hospital and Professor Ed Wraith, the director of the Genetic Medicine Unit at St Mary’s Hospital. The group works on pathology, diagnosis and clinical development of treatments for neurodegenerative lysosomal storage diseases and glioblastoma, with expertise in development of drug, gene and cellular therapies. The first therapy developed in the lab started in phase III clinical trial in mid 2015.