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Employment (1)

University of Washington: Seattle, US

2021-01 to present | HHMI Helen Hay Whitney Postdoc Fellow (Biochemistry)
Employment
Source: Self-asserted source
Jason Zhaoxing Zhang

Education and qualifications (2)

University of California San Diego: La Jolla, CA, US

2015-09 to 2020-10 | PhD (Bioengineering)
Education
Source: Self-asserted source
Jason Zhaoxing Zhang

University of California Berkeley: Berkeley, CA, US

2012-08 to 2014-12 | BS (Bioengineering)
Education
Source: Self-asserted source
Jason Zhaoxing Zhang

Funding (3)

De novo designed Ras tools to uncover the mechanisms underlying drug resistance

Source: Self-asserted source
Jason Zhaoxing Zhang

De novo designed protein tools to map the activity and function of endogenous and oncogenic Ras

2022-06 to 2025-06 | Award
Helen Hay Whitney Foundation (New York City, New York, US)
Source: Self-asserted source
Jason Zhaoxing Zhang

Illuminating Beta-Adrenergic Signaling with a new class of biosensors FluoSTEP

2017-05 to 2020-05 | Award
National Science Foundation (Alexandria, US)
Source: Self-asserted source
Jason Zhaoxing Zhang

Works (18)

De novo designed Hsp70 activator dissolves intracellular condensates

Cell Chemical Biology
2025-03 | Journal article
DOI: 10.1016/j.chembiol.2025.01.006
Contributors: Jason Z. Zhang; Nathan Greenwood; Jason Hernandez; Josh T. Cuperus; Buwei Huang; Bryan D. Ryder; Christine Queitsch; Jason E. Gestwicki; David Baker
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Crossref

Designed endocytosis-inducing proteins degrade targets and amplify signals

Nature
2025-02-20 | Journal article
DOI: 10.1038/s41586-024-07948-2
Contributors: Buwei Huang; Mohamad Abedi; Green Ahn; Brian Coventry; Isaac Sappington; Cong Tang; Rong Wang; Thomas Schlichthaerle; Jason Z. Zhang; Yujia Wang et al.
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Crossref

Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance

Nature Chemical Biology
2025-01 | Journal article
DOI: 10.1038/s41589-024-01684-4
Contributors: Jason Z. Zhang; Shao-En Ong; David Baker; Dustin J. Maly
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Crossref

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

Nature Biotechnology
2024-12 | Journal article
DOI: 10.1038/s41587-023-02107-w
Contributors: Jason Z. Zhang; William H. Nguyen; Nathan Greenwood; John C. Rose; Shao-En Ong; Dustin J. Maly; David Baker
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Crossref

Computational design of non-porous pH-responsive antibody nanoparticles

Nature Structural & Molecular Biology
2024-09 | Journal article
DOI: 10.1038/s41594-024-01288-5
Contributors: Erin C. Yang; Robby Divine; Marcos C. Miranda; Andrew J. Borst; Will Sheffler; Jason Z. Zhang; Justin Decarreau; Amijai Saragovi; Mohamad Abedi; Nicolas Goldbach et al.
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Crossref

De novodesign of Ras isoform selective binders

2024-08-30 | Preprint
DOI: 10.1101/2024.08.29.610300
Contributors: Jason Z. Zhang; Xinting Li; Alexa Rane Batingana; Caixuan Liu; Hanlun Jiang; Kevin Shannon; Benjamin J. Huang; Kejia Wu; David Baker
Source: check_circle
Crossref

Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance

2023-10-04 | Preprint
DOI: 10.1101/2023.10.02.560617
Contributors: Jason Z. Zhang; Shao-En Ong; David Baker; Dustin J. Maly
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Crossref

De novodesigned Hsp70 activator dissolves intracellular condensates

2023-09-19 | Preprint
DOI: 10.1101/2023.09.18.558356
Contributors: Jason Z Zhang; Nathan Greenwood; Jason Hernandez; Josh T Cuperus; Buwei Huang; Bryan D Ryder; Christine Queitsch; Jason E Gestwicki; David Baker
Source: check_circle
Crossref

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation

2023-08-21 | Preprint
DOI: 10.1101/2023.08.19.553321
Contributors: Buwei Huang; Mohamad Abedi; Green Ahn; Brian Coventry; Isaac Sappington; Rong Wang; Thomas Schlichthaerle; Jason Z. Zhang; Yujia Wang; Inna Goreshnik et al.
Source: Self-asserted source
Jason Zhaoxing Zhang

Computational design of non-porous, pH-responsive antibody nanoparticles

2023-04-18 | Preprint
DOI: 10.1101/2023.04.17.537263
Contributors: Erin C. Yang; Robby Divine; Marcos C. Miranda; Andrew J. Borst; Will Sheffler; Jason Z Zhang; Justin Decarreau; Amijai Saragovi; Mohamad Abedi; Nicolas Goldbach et al.
Source: check_circle
Crossref

De novo design of luciferases using deep learning

Nature
2023-02-23 | Journal article
DOI: 10.1038/s41586-023-05696-3
Contributors: Andy Hsien-Wei Yeh; Christoffer Norn; Yakov Kipnis; Doug Tischer; Samuel J. Pellock; Declan Evans; Pengchen Ma; Gyu Rie Lee; Jason Z. Zhang; Ivan Anishchenko et al.
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Crossref

Computationally designed sensors for endogenous Ras activity reveal signaling effectors within oncogenic granules

2022-11-23 | Preprint
DOI: 10.1101/2022.11.22.517009
Contributors: Jason Z. Zhang; William H. Nguyen; Nathan Greenwood; John C. Rose; Shao-En Ong; Dustin J. Maly; David Baker
Source: check_circle
Crossref

Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants

Nature Biotechnology
2022-09 | Journal article
DOI: 10.1038/s41587-022-01280-8
Contributors: Jason Z. Zhang; Hsien-Wei Yeh; Alexandra C. Walls; Basile I. M. Wicky; Kaitlin R. Sprouse; Laura A. VanBlargan; Rebecca Treger; Alfredo Quijano-Rubio; Minh N. Pham; John C. Kraft et al.
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Crossref

Characterizing protein kinase A (PKA) subunits as macromolecular regulators of PKA RIα liquid–liquid phase separation

The Journal of Chemical Physics
2021-06-14 | Journal article
DOI: 10.1063/5.0049810
Contributors: Surl-Hee Ahn; Sanbo Qin; Jason Z. Zhang; J. Andrew McCammon; Jin Zhang; Huan-Xiang Zhou
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Crossref

FluoSTEPs: Fluorescent biosensors for monitoring compartmentalized signaling within endogenous microdomains

Science Advances
2021-05-21 | Journal article
DOI: 10.1126/sciadv.abe4091
Contributors: Brian Tenner; Jason Z. Zhang; Yonghoon Kwon; Veronica Pessino; Siyu Feng; Bo Huang; Sohum Mehta; Jin Zhang
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Crossref

An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

Nature Chemical Biology
2021-01-28 | Journal article
DOI: 10.1038/s41589-020-00660-y
Contributors: Jin-Fan Zhang; Bian Liu; Ingie Hong; Albert Mo; Richard H. Roth; Brian Tenner; Wei Lin; Jason Z. Zhang; Rosana S. Molina; Mikhail Drobizhev et al.
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Crossref

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

Cell
2020-09 | Journal article
DOI: 10.1016/j.cell.2020.07.043
Contributors: Jason Z. Zhang; Tsan-Wen Lu; Lucas M. Stolerman; Brian Tenner; Jessica R. Yang; Jin-Fan Zhang; Martin Falcke; Padmini Rangamani; Susan S. Taylor; Sohum Mehta et al.
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Crossref

Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling

PLOS Biology
2020-09-03 | Journal article
DOI: 10.1371/journal.pbio.3000866
Contributors: Jason Z. Zhang; Carole A. Parent; Andy H. Nguyen; Shigeki Miyamoto; Joan Heller Brown; Andrew D. McCulloch; Jin Zhang
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Crossref

Peer review (4 reviews for 1 publication/grant)

Review activity for STAR protocols. (4)
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