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Employment (2)

University of North Carolina at Chapel Hill: Chapel Hill, NC, US

1999-07-01 to present | Distinguished Professor (Chemistry, Biochemistry, Microbiology, iBGS)
Employment
Source: Self-asserted source
Matthew Redinbo

University of Washington: Seattle, WA, US

1995-09-01 to 1999-06-01 | Postdoctoral Fellow (Structural Biology)
Employment
Source: Self-asserted source
Matthew Redinbo

Education and qualifications (2)

University of California Los Angeles: Los Angeles, CA, US

1990-09-01 to 1995-05-15 | PhD, Biochemistry (Chemistry and Biochemistry)
Education
Source: Self-asserted source
Matthew Redinbo

University of California Davis: Davis, CA, US

1985-09-01 to 1990-06-15 | BS (Biochemistry)
Education
Source: Self-asserted source
Matthew Redinbo

Works (14)

The role of gut microbial β-glucuronidases in carcinogenesis and cancer treatment: a scoping review

Journal of Cancer Research and Clinical Oncology
2024-11-13 | Journal article
DOI: 10.1007/s00432-024-06028-2
Contributors: Lars E. Hillege; Milou A. M. Stevens; Paulien A. J. Kristen; Judith de Vos-Geelen; John Penders; Matthew R. Redinbo; Marjolein L. Smidt
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Crossref

Diverse but desolate landscape of gut microbial azoreductases: A rationale for idiopathic IBD drug response

Gut Microbes
2023-12-31 | Journal article
DOI: 10.1080/19490976.2023.2203963
Contributors: Joshua B. Simpson; Josh J. Sekela; Benjamin S. Carry; Violet Beaty; Shakshi Patel; Matthew. R. Redinbo
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Crossref

Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate

Cell Chemical Biology
2023-11 | Journal article
DOI: 10.1016/j.chembiol.2023.07.015
Contributors: Amanda L. Graboski; Mark E. Kowalewski; Joshua B. Simpson; Xufeng Cao; Mary Ha; Jianan Zhang; William G. Walton; Daniel P. Flaherty; Matthew R. Redinbo
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Crossref

Microbial β-glucuronidases drive human periodontal disease etiology

Science Advances
2023-05-05 | Journal article
DOI: 10.1126/sciadv.adg3390
Contributors: Adam D. Lietzan; Joshua B. Simpson; William G. Walton; Parth B. Jariwala; Yongmei Xu; Marcella H. Boynton; Jian Liu; Matthew R. Redinbo
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Crossref

Multi-omic analysis of host-microbial interactions central to the gut-brain axis

Molecular Omics
2022 | Journal article
DOI: 10.1039/D2MO00205A
Contributors: Joshua B. Simpson; Matthew R. Redinbo
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Crossref

A structural metagenomics pipeline for examining the gut microbiome

Current Opinion in Structural Biology
2022-08 | Journal article
DOI: 10.1016/j.sbi.2022.102416
Contributors: Morgan E. Walker; Joshua B. Simpson; Matthew R. Redinbo
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Crossref

The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652

Xenobiotica
2022-08-03 | Journal article
DOI: 10.1080/00498254.2022.2128468
Contributors: Anna Kerins; Marta Koszyczarek; Caroline Smith; Phil Butler; Rob Riley; Vamsi Madgula; Nilkanth Naik; Matthew R. Redinbo; Ian D. Wilson
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Crossref

Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases

Biochemistry
2020-10-13 | Journal article
DOI: 10.1021/acs.biochem.0c00711
Contributors: Samantha M. Ervin; Joshua B. Simpson; Morgan E. Gibbs; Benjamin C. Creekmore; Lauren Lim; William G. Walton; Raad Z. Gharaibeh; Matthew R. Redinbo
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Crossref

Gut-Derived Protein-Bound Uremic Toxins

Toxins
2020-09-11 | Journal article
DOI: 10.3390/toxins12090590
Contributors: Amanda L. Graboski; Matthew R. Redinbo
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Crossref
grade
Preferred source (of 2)‎

Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens

Journal of Biological Chemistry
2019-12 | Journal article
DOI: 10.1074/jbc.RA119.010950
Contributors: Samantha M. Ervin; Hao Li; Lauren Lim; Lee R. Roberts; Xue Liang; Sridhar Mani; Matthew R. Redinbo
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Crossref

Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases

ACS Chemical Biology
2019-12-20 | Journal article
DOI: 10.1021/acschembio.9b00663
Contributors: Samantha M. Ervin; Ronan P. Hanley; Lauren Lim; William G. Walton; Kenneth H. Pearce; Aadra P. Bhatt; Lindsey I. James; Matthew R. Redinbo
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Crossref

Mouse Gut Microbiome-Encoded β-Glucuronidases Identified Using Metagenome Analysis Guided by Protein Structure

mSystems
2019-08-27 | Journal article
DOI: 10.1128/mSystems.00452-19
Contributors: Benjamin C. Creekmore; Josh H. Gray; William G. Walton; Kristen A. Biernat; Michael S. Little; Yongmei Xu; Jian Liu; Raad Z. Gharaibeh; Matthew R. Redinbo; Peter J. Turnbaugh
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Crossref

Selecting a Single Stereocenter: The Molecular Nuances That Differentiate β-Hexuronidases in the Human Gut Microbiome

Biochemistry
2019-03-05 | Journal article
DOI: 10.1021/acs.biochem.8b01285
Contributors: Samuel J. Pellock; William G. Walton; Matthew R. Redinbo
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Crossref

Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells

ACS Infectious Diseases
2018-01-12 | Journal article
DOI: 10.1021/acsinfecdis.7b00139
Contributors: Aadra P. Bhatt; Dulan B. Gunasekara; Jennifer Speer; Mark I. Reed; Alexis N. Peña; Bentley R. Midkiff; Scott T. Magness; Scott J. Bultman; Nancy L. Allbritton; Matthew R. Redinbo
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Crossref

Peer review (9 reviews for 5 publications/grants)

Review activity for ACS infectious diseases. (3)
Review activity for Analytical chemistry. (1)
Review activity for Biochemistry. (3)
Review activity for Journal of medicinal chemistry. (1)
Review activity for Toxins. (1)
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