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Dariusz Lachowski is a Cesar Nombela Research Fellow at Universidad Carlos III de Madrid. His project focuses on the use of tissue engineering and mechanobiology to create new therapeutic tools - 3D grafts engineered by tuning the physical and chemical factors of the cellular microenvironment to control osteochondral differentiation of human mesenchymal stem cells, with the ultimate goal of engineering the cartilage/bone interface to improve the treatment of osteoarthritis and cartilage injuries.
Dariusz received PhD in bioengineering at Imperial College London. His doctoral studies were focused on discovering novel mechanotransduction signalling pathways in hepatic and pancreatic stellate cells. He applied a variety of model in vitro system to recreate microenvironment associated with healthy tissue, cirrhosis, hepatocellular carcinoma, and pancreatic adenocarcinoma. He was a Co-I on a project funded by Innovate UK that allowed Dariusz to translate his academic expertise in bioengineering into biotechnology industry, developing self-assembling peptide matrices as a platform for cell biology studies.