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Keywords

RNA methylation, RNA virus, coronavirus, viral infection and replication

Countries

China

Activities

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Employment (1)

College of Life Sciences, Wuhan University: Wuhan, Hubei, CN

2016-12-01 to present | PI / Professor (State Key Laboratory of Virology)
Employment
Source: Self-asserted source
Yu Chen

Education and qualifications (1)

Wuhan University: Wuhan, Hubei, CN

2003-09-01 to 2009-06-30 | Ph.D (Department of Microbiology)
Education
Source: Self-asserted source
Yu Chen

Works (34)

Generation of a biosafety mouse model infection for SARS-CoV-2 replicon delivery particles

2024-11-10 | Preprint
DOI: 10.1101/2024.11.10.622838
Contributors: Yingjian Li; Xiaoya Huang; Jikai Deng; Xue Tan; Qianyun Liu; Li Zhou; Yu Chen
Source: check_circle
Crossref

Human adenoviruses: A suspect behind the outbreak of acute hepatitis in children amid the COVID-19 pandemic

Cell Insight
2022-08 | Journal article
DOI: 10.1016/j.cellin.2022.100043
Contributors: Hongyun Wang; Shimin Yang; Jiejie Liu; Zhiying Fu; Yingle Liu; Li Zhou; Haitao Guo; Ke Lan; Yu Chen
Source: check_circle
Crossref

Emerging SARS-CoV-2 variants: Why, how, and what's next?

Cell Insight
2022-06 | Journal article
DOI: 10.1016/j.cellin.2022.100029
Contributors: Yu Chen; Qianyun Liu; Li Zhou; You Zhou; Huan Yan; Ke Lan
Source: check_circle
Crossref

An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis

Proceedings of the National Academy of Sciences
2021-01-19 | Journal article
DOI: 10.1073/pnas.2015416118
Contributors: Panpan Hou; Penghui Jia; Kongxiang Yang; Zibo Li; Tian Tian; Yuxin Lin; Weijie Zeng; Fan Xing; Yu Chen; Chunmei Li et al.
Source: check_circle
Crossref

Many bat species are not potential hosts of SARS-CoV and SARS-CoV-2: Evidence from ACE2 receptor usage

2020-09-08 | Preprint
DOI: 10.1101/2020.09.08.284737
Contributors: Huan Yan; Hengwu Jiao; Qianyun Liu; Zhen Zhang; Xin Wang; Ming Guo; Bing-Jun Wang; Ke Lan; Yu Chen; Huabin Zhao
Source: check_circle
Crossref

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Protein & Cell
2020-08-04 | Journal article
DOI: 10.1007/s13238-020-00768-w
Part of ISSN: 1674-800X
Part of ISSN: 1674-8018
Source: Self-asserted source
Yu Chen

Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals

Nature
2020-06-25 | Journal article
DOI: 10.1038/s41586-020-2271-3
Contributors: Yuan Liu; Zhi Ning; Yu Chen; Ming Guo; Yingle Liu; Nirmal Kumar Gali; Li Sun; Yusen Duan; Jing Cai; Dane Westerdahl et al.
Source: check_circle
Crossref

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Journal of Medical Virology
2020-04 | Journal article
DOI: 10.1002/jmv.25681
Part of ISSN: 0146-6615
Part of ISSN: 1096-9071
Source: Self-asserted source
Yu Chen

Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets

Emerging Microbes & Infections
2020-01-01 | Journal article
DOI: 10.1080/22221751.2020.1772679
Part of ISSN: 2222-1751
Source: Self-asserted source
Yu Chen

ddPCR: a more accurate tool for SARS-CoV-2 detection in low viral load specimens

Emerging Microbes & Infections
2020-01-01 | Journal article
DOI: 10.1080/22221751.2020.1772678
Part of ISSN: 2222-1751
Source: Self-asserted source
Yu Chen

RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak

Emerging Microbes & Infections
2020-01-01 | Journal article
DOI: 10.1080/22221751.2020.1725399
Part of ISSN: 2222-1751
Source: Self-asserted source
Yu Chen

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Emerging Microbes & Infections
2020-01-01 | Journal article
DOI: 10.1080/22221751.2020.1747363
Part of ISSN: 2222-1751
Source: Self-asserted source
Yu Chen

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus

PLOS Pathogens
2019-10-11 | Journal article
DOI: 10.1371/journal.ppat.1008079
Part of ISSN: 1553-7374
Source: Self-asserted source
Yu Chen

The RNA Capping Enzyme Domain in Protein A is Essential for Flock House Virus Replication

Viruses
2018-09-09 | Journal article
DOI: 10.3390/v10090483
Part of ISSN: 1999-4915
Source: Self-asserted source
Yu Chen

PTEN-L promotes type I interferon responses and antiviral immunity

Cellular & Molecular Immunology
2018-01 | Journal article
DOI: 10.1038/cmi.2017.102
Part of ISSN: 1672-7681
Part of ISSN: 2042-0226
Source: Self-asserted source
Yu Chen

Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat

Retrovirology
2017-12 | Journal article
DOI: 10.1186/s12977-017-0338-5
Part of ISSN: 1742-4690
Source: Self-asserted source
Yu Chen

A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220

Cancer Research
2017-08-15 | Journal article
DOI: 10.1158/0008-5472.can-16-1627
Part of ISSN: 0008-5472
Part of ISSN: 1538-7445
Source: Self-asserted source
Yu Chen

Electron microscopy studies of the coronavirus ribonucleoprotein complex

Protein & Cell
2017-03 | Journal article
DOI: 10.1007/s13238-016-0352-8
Part of ISSN: 1674-800X
Part of ISSN: 1674-8018
Source: Self-asserted source
Yu Chen

The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription

PLOS ONE
2016-10-13 | Journal article
DOI: 10.1371/journal.pone.0164471
Part of ISSN: 1932-6203
Source: Self-asserted source
Yu Chen

Identification and Characterization of a Ribose 2′-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales

Journal of Virology
2016-08-01 | Journal article
DOI: 10.1128/jvi.00658-16
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Source: Self-asserted source
Yu Chen

The tumor suppressor PTEN has a critical role in antiviral innate immunity

Nature Immunology
2016-03 | Journal article
DOI: 10.1038/ni.3311
Part of ISSN: 1529-2908
Part of ISSN: 1529-2916
Source: Self-asserted source
Yu Chen

Molecular mechanisms of coronavirus RNA capping and methylation

Virologica Sinica
2016-02 | Journal article
DOI: 10.1007/s12250-016-3726-4
Part of ISSN: 1674-0769
Part of ISSN: 1995-820X
Source: Self-asserted source
Yu Chen

Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus

Virus Research
2015-10 | Journal article
DOI: 10.1016/j.virusres.2015.05.018
Part of ISSN: 0168-1702
Source: Self-asserted source
Yu Chen

Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived PeptideIn VitroandIn VivoTo Reduce Replication and Pathogenesis

Journal of Virology
2015-08-15 | Journal article
DOI: 10.1128/jvi.00948-15
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Source: Self-asserted source
Yu Chen

Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome

Journal of General Virology
2015-08-01 | Journal article
DOI: 10.1099/vir.0.000159
Part of ISSN: 0022-1317
Part of ISSN: 1465-2099
Source: Self-asserted source
Yu Chen

Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc (and STAT) interactor

Virologica Sinica
2015-04 | Journal article
DOI: 10.1007/s12250-015-3581-8
Part of ISSN: 1674-0769
Part of ISSN: 1995-820X
Source: Self-asserted source
Yu Chen

VHL negatively regulates SARS coronavirus replication by modulating nsp16 ubiquitination and stability

Biochemical and Biophysical Research Communications
2015-04 | Journal article
DOI: 10.1016/j.bbrc.2015.02.097
Part of ISSN: 0006-291X
Source: Self-asserted source
Yu Chen
grade
Preferred source (of 2)‎

Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase

Antiviral Research
2014-04 | Journal article
DOI: 10.1016/j.antiviral.2014.02.002
Part of ISSN: 0166-3542
Source: Self-asserted source
Yu Chen

Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP

Virus Research
2013-09 | Journal article
DOI: 10.1016/j.virusres.2013.05.001
Part of ISSN: 0168-1702
Source: Self-asserted source
Yu Chen

Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase

Journal of Virology
2013-06-01 | Journal article
DOI: 10.1128/jvi.00061-13
Part of ISSN: 0022-538X
Source: Self-asserted source
Yu Chen

Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2′-O-methyltransferase activity of nsp10/nsp16 complex

Virus Research
2012-08 | Journal article
DOI: 10.1016/j.virusres.2012.05.017
Part of ISSN: 0168-1702
Source: Self-asserted source
Yu Chen

Biochemical and Structural Insights into the Mechanisms of SARS Coronavirus RNA Ribose 2′-O-Methylation by nsp16/nsp10 Protein Complex

PLoS Pathogens
2011-10-13 | Journal article
DOI: 10.1371/journal.ppat.1002294
Part of ISSN: 1553-7374
Source: Self-asserted source
Yu Chen

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

Proceedings of the National Academy of Sciences
2009-03-03 | Journal article
DOI: 10.1073/pnas.0808790106
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Yu Chen

Identification of Novel Subgenomic RNAs and Noncanonical Transcription Initiation Signals of Severe Acute Respiratory Syndrome Coronavirus

Journal of Virology
2005-05-01 | Journal article
DOI: 10.1128/jvi.79.9.5288-5295.2005
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Source: Self-asserted source
Yu Chen
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