Of mice and men: how animal models advance our understanding of T-cell function in RA.
Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow.
Proteoglycan aggrecan conducting T cell activation and apoptosis in a murine model of rheumatoid arthritis.
Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study.
Epigenetics in the pathogenesis of rheumatoid arthritis.
Genetics of rheumatoid arthritis - a comprehensive review.
ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy.
Pharmacogenetics and pharmacogenomics in rheumatology.
Differentially expressed epigenome modifiers, including aurora kinases A and B, in immune cells in rheumatoid arthritis in humans and mouse models.
The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis.
Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model.
TSG-6 protein is crucial for the development of pulmonary hyaluronan deposition, eosinophilia, and airway hyperresponsiveness in a murine model of asthma.
Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6.
Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis.
Arthritogenic T cells drive the recovery of autoantibody-producing B cell homeostasis and the adoptive transfer of arthritis in SCID mice.
Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.
Species-specific biological effects of FGF-2 in articular cartilage: implication for distinct roles within the FGF receptor family.
Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.
T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice.
Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models.
In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis.
TSG-6 protein, a negative regulator of inflammatory arthritis, forms a ternary complex with murine mast cell tryptases and heparin.
Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.
Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.
Osteoarthritis-like damage of cartilage in the temporomandibular joints in mice with autoimmune inflammatory arthritis.
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
Alteration in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6/SHP1) may contribute to neutrophilic dermatoses.
Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic mice.
Modulation of hyaluronan production by CD44 positive glioma cells.
Immunosenescence and its potential modulation: lessons from mouse models.
IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis.
Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints.
The genetic background of ankylosing spondylitis.
Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair.
Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice.
BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.
Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis.
CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis.
Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.
TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.
Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption.
Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation.
Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages.
Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice.
Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis.
Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis.
Visualization and in situ analysis of leukocyte trafficking into the ankle joint in a systemic murine model of rheumatoid arthritis.
CD44, but not l-selectin, is critically involved in leucocyte migration into the skin in a murine model of allergic dermatitis.
Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.
Genetic control of experimental spondylarthropathy.
Effects of soluble metals on human peri-implant cells.
A longitudinal study on an autoimmune murine model of ankylosing spondylitis.
T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis.
Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation.
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice.
TSG-6 modulates the interaction between hyaluronan and cell surface CD44.
Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background.
Expression of L-selectin, but not CD44, is required for early neutrophil extravasation in antigen-induced arthritis.
Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype.
Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis.
Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis.
Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan.
Differential recognition of altered peptide ligands distinguishes two functionally discordant (arthritogenic and nonarthritogenic) autoreactive T cell hybridoma clones.
Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis.
Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice.
IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism.
Role of the extracellular and cytoplasmic domains of CD44 in the rolling interaction of lymphoid cells with hyaluronan under physiologic flow.
Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci.
Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics.
CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis.
Trafficking of CD44-deficient murine lymphocytes under normal and inflammatory conditions.
Mice lacking endogenous major histocompatibility complex class II develop arthritis resembling psoriatic arthritis at an advanced age.
IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms.
Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination.
Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice.
Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis.
Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6.
T and B cell recovery in arthritis adoptively transferred to SCID mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system.
Major histocompatibility complex controls susceptibility and dominant inheritance, but not the severity of the disease in mouse models of rheumatoid arthritis.
Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis.
Increased resistance to collagen-induced arthritis in CD44-deficient DBA/1 mice.
Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-alpha-stimulated gene-6) in murine models of experimental arthritis.
Differential lymphocyte reactivity to serum-derived metal-protein complexes produced from cobalt-based and titanium-based implant alloy degradation.
Antibody-induced shedding of CD44 from adherent cells is linked to the assembly of the cytoskeleton.
Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation.
Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis.
Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease.
A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis.
Vitaxin applied molecular evolution.
Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway.
A triple assay technique for the evaluation of metal-induced, delayed-type hypersensitivity responses in patients with or receiving total joint arthroplasty.
Adhesion of lymphoid cells to CD44-specific substrata: the consequences of attachment depend on the ligand.
Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis.
Systemic metal-protein binding associated with total joint replacement arthroplasty.
Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis.
Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines.
Modulation of hyaluronan receptor (CD44) function in vivo in a murine model of rheumatoid arthritis.
Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage.
Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation.
CD44 expression by leucocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro.
Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase.
Particulate-Induced, Prostaglandin- and Cytokine-Mediated Bone Resorption in an Experimental System and in Failed Joint Replacements.
Immunoregulation of Proteoglycan-Induced Arthritis in Balb/c Mice.
Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints.
Aggrecan: A Target Molecule of Autoimmune Reactions.
The potential role of fibroblasts in periprosthetic osteolysis: fibroblast response to titanium particles.
Antigen-specific B cells present cartilage proteoglycan (aggrecan) to an autoreactive T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.
A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice.
Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis.
Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis.
Interferon-gamma but not granulocyte/macrophage colony-stimulating factor augments proteoglycan presentation by synovial cells and chondrocytes to an autopathogenic T cell hybridoma.
The role of adhesion molecules in the development of autoimmune arthritis.
Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis.
Mediators and autopathogenic effector cells in proteoglycan-induced arthritic and clinically asymptomatic BALB/c mice.
Migration and homing of lymphocytes to lymphoid and synovial tissues in proteoglycan-induced murine arthritis.
Functional assessment of joint use in experimental inflammatory murine arthritis.
Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide.
Proteoglycan-specific autoreactive antibodies and T-lymphocytes in experimental arthritis and human rheumatoid joint diseases.
Cartilage proteoglycan-induced arthritis in BALB/c mice. Antibodies that recognize human and mouse cartilage proteoglycan and can cause depletion of cartilage proteoglycan with little or no synovitis.
Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice.
Isolation of proteoglycan-specific T lymphocytes from patients with ankylosing spondylitis.
Cartilage proteoglycans as potential autoantigens in humans and in experimental animals.
Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan.
Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology.
Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans.
Monoclonal antibodies to different protein-related epitopes of human articular cartilage proteoglycans.
Antigenic profiles of human, bovine and canine articular chondrocytes.
Serum IgE level in systemic lupus erythematosus.
Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II.