Personal information

No personal information available

Activities

Employment (1)

Max Planck Institute of Molecular Physiology: Dortmund, DE

2015-04-01 to present | Medicinal Chemistry (Chemical Biology / COMAS)
Employment
Source: Self-asserted source
Axel Pahl

Works (18)

Identification of lysosomotropism using explainable machine learning and morphological profiling cell painting data

RSC Medicinal Chemistry
2024 | Journal article
Contributors: Aishvarya Tandon; Anna Santura; Herbert Waldmann; Axel Pahl; Paul Czodrowski
Source: check_circle
Crossref

Identification of readily available pseudo-natural products

RSC Medicinal Chemistry
2024 | Journal article
Contributors: Axel Pahl; Oleksandr O. Grygorenko; Ivan S. Kondratov; Herbert Waldmann
Source: check_circle
Crossref

Discovery of a Novel Pseudo‐Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling

Advanced Science
2024-06 | Journal article
Contributors: Lin Wang; Furkan Yilmaz; Okan Yildirim; Beate Schölermann; Sukdev Bag; Luca Greiner; Axel Pahl; Sonja Sievers; Rebecca Scheel; Carsten Strohmann et al.
Source: check_circle
Crossref

Collective Synthesis of Sarpagine and Macroline Alkaloid‐Inspired Compounds

Chemistry – A European Journal
2024-01-22 | Journal article
Contributors: Hikaru Aoyama; Caitlin Davies; Jie Liu; Axel Pahl; Jan‐Lukas Kirchhoff; Rebecca Scheel; Sonja Sievers; Carsten Strohmann; Michael Grigalunas; Herbert Waldmann
Source: check_circle
Crossref

Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair

ChemBioChem
2023-12-14 | Journal article
Contributors: Dale Corkery; Andrei Ursu; Belén Lucas; Michael Grigalunas; Simon Kriegler; Rosario Oliva; Robert Dec; Sandra Koska; Axel Pahl; Sonja Sievers et al.
Source: check_circle
Crossref

Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space

Angewandte Chemie
2023-11-27 | Journal article
Contributors: Jianing Xie; Axel Pahl; Adrian Krzyzanowski; Anna Krupp; Jie Liu; Sandra Koska; Beate Schölermann; Ruirui Zhang; Jana Bonowski; Sonja Sievers et al.
Source: check_circle
Crossref

Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space

Angewandte Chemie International Edition
2023-11-27 | Journal article
Contributors: Jianing Xie; Axel Pahl; Adrian Krzyzanowski; Anna Krupp; Jie Liu; Sandra Koska; Beate Schölermann; Ruirui Zhang; Jana Bonowski; Sonja Sievers et al.
Source: check_circle
Crossref

Detection of a Mitochondrial Stress Phenotype using the Cell Painting Assay

2023-11-08 | Preprint
Contributors: Soheila Rezaei Adariani; Daya Agne; Sandra Koska; Annina Burhop; Jens Warmers; Petra Janning; Malte Metz; Axel Pahl; Sonja Sievers; Herbert Waldmann et al.
Source: check_circle
Crossref

Illuminating Dark Chemical Matter using the Cell Painting Assay

2023-05-31 | Preprint
Contributors: Axel Pahl; Jie Liu; Sohan Patil; Soheila Rezaei Adariani; Beate Schölermann; Jens Warmers; Jana Bonowski; Sandra Koska; Sonja Sievers; Slava Ziegler et al.
Source: check_circle
Crossref

Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3‐Rich Compounds With Distinct Phenotypic Effects

Chemistry – A European Journal
2023-05-08 | Journal article
Contributors: Ephraim A. Okolo; Axel Pahl; Sonja Sievers; Christopher M. Pask; Adam Nelson; Stephen P. Marsden
Source: check_circle
Crossref

Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone

Chemistry – A European Journal
2022-12 | Journal article
Contributors: Michael Grigalunas; Sohan Patil; Adrian Krzyzanowski; Axel Pahl; Jana Flegel; Beate Schölermann; Jianing Xie; Sonja Sievers; Slava Ziegler; Herbert Waldmann
Source: check_circle
Crossref

Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules

2022-08-15 | Preprint
Contributors: Axel Pahl; Beate Schölermann; Marion Rusch; Mark Dow; Christian Hedberg; Adam Nelson; Sonja Sievers; Herbert Waldmann; Slava Ziegler
Source: check_circle
Crossref

Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis

Cell Chemical Biology
2021-12 | Journal article
Part of ISSN: 2451-9456
Source: Self-asserted source
Axel Pahl

Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds

Cell Chemical Biology
2021-12 | Journal article
Part of ISSN: 2451-9456
Source: Self-asserted source
Axel Pahl

Natural product fragment combination to performance-diverse pseudo-natural products

Nature Communications
2021-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Axel Pahl

Pseudonatural Products Occur Frequently in Biologically Relevant Compounds

Journal of Chemical Information and Modeling
2021-11-22 | Journal article
Part of ISSN: 1549-9596
Part of ISSN: 1549-960X
Source: Self-asserted source
Axel Pahl

Combination of Pseudo‐Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo‐Sesquiterpenoid Alkaloids

Angewandte Chemie International Edition
2021-09-20 | Journal article
Part of ISSN: 1433-7851
Part of ISSN: 1521-3773
Source: Self-asserted source
Axel Pahl

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

Angewandte Chemie International Edition
2015-12-21 | Journal article
Part of ISSN: 1433-7851
Part of ISSN: 1521-3773
Source: Self-asserted source
Axel Pahl