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Works (11)

Evaluation of the need for dosing adaptations in obese patients for surgical antibiotic prophylaxis: a model-based analysis of cefazolin pharmacokinetics

British Journal of Anaesthesia
2025-02 | Journal article
Contributors: Davide Bindellini; Philipp Simon; David Busse; Robin Michelet; David Petroff; Linda B.S. Aulin; Christoph Dorn; Markus Zeitlinger; Wilhelm Huisinga; Hermann Wrigge et al.
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A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody

CPT: Pharmacometrics & Systems Pharmacology
2024-12-09 | Journal article
Contributors: Robin Michelet; Klas Petersson; Marc C. Huisman; C. Willemien Menke‐van der Houven van Oordt; Iris H. C. Miedema; Andrea Thiele; Ghazal Montaseri; Alejandro Pérez‐Pitarch; David Busse
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Evaluating prediction methods for glomerular filtration to optimise drug doses in obese and nonobese patients

British Journal of Clinical Pharmacology
2022-06 | Journal article
Contributors: David Busse; Jens Markus Borghardt; David Petroff; Alice Pevzner; Christoph Dorn; Nahed El‐Najjar; Wilhelm Huisinga; Hermann Wrigge; Philipp Simon; Charlotte Kloft
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High-Dosage Fosfomycin Results in Adequate Plasma and Target-Site Exposure in Morbidly Obese and Nonobese Nonhyperfiltration Patients

Antimicrobial Agents and Chemotherapy
2022-06-21 | Journal article
Contributors: D. Busse; P. Simon; D. Petroff; N. El-Najjar; L. Schmitt; D. Bindellini; A. Dietrich; M. Zeitlinger; W. Huisinga; R. Michelet et al.
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Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients

Clinical Pharmacokinetics
2022-05 | Journal article
Contributors: David Busse; Philipp Simon; Lisa Schmitt; David Petroff; Christoph Dorn; Arne Dietrich; Markus Zeitlinger; Wilhelm Huisinga; Robin Michelet; Hermann Wrigge et al.
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Similar Piperacillin/Tazobactam Target Attainment in Obese versus Nonobese Patients despite Differences in Interstitial Tissue Fluid Pharmacokinetics

Pharmaceutics
2021-08-31 | Journal article
Contributors: David Busse; Philipp Simon; David Petroff; Christoph Dorn; Lisa Schmitt; Davide Bindellini; Alexander Kratzer; Arne Dietrich; Markus Zeitlinger; Wilhelm Huisinga et al.
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Quantification of microdialysis related variability in humans: Clinical trial design recommendations

European Journal of Pharmaceutical Sciences
2021-02 | Journal article
Contributors: David Busse; Philipp Simon; Robin Michelet; Lisa Ehmann; Frank Mehner; Christoph Dorn; Alexander Kratzer; Wilhelm Huisinga; Hermann Wrigge; David Petroff et al.
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Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients—A Controlled Clinical Trial

Antibiotics
2020-12-21 | Journal article
Contributors: Philipp Simon; David Petroff; David Busse; Jana Heyne; Felix Girrbach; Arne Dietrich; Alexander Kratzer; Markus Zeitlinger; Charlotte Kloft; Frieder Kees et al.
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Industrial approach to determine the relative contribution of seven major UGT isoforms to hepatic glucuronidation

Journal of Pharmaceutical Sciences
2020-04 | Journal article
Part of ISSN: 0022-3549
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David Busse

Linezolid Concentrations in Plasma and Subcutaneous Tissue are Reduced in Obese Patients, Resulting in a Higher Risk of Underdosing in Critically Ill Patients: A Controlled Clinical Pharmacokinetic Study

Journal of Clinical Medicine
2020-04-09 | Journal article
Contributors: Philipp Simon; David Busse; David Petroff; Christoph Dorn; Lisa Ehmann; Sophie Hochstädt; Felix Girrbach; Arne Dietrich; Markus Zeitlinger; Frieder Kees et al.
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Comparison of pharmacokinetics and the exposure–response relationship of dapagliflozin between adolescent/young adult and adult patients with type 1 diabetes mellitus

British Journal of Clinical Pharmacology
2019-08 | Journal article
Part of ISSN: 0306-5251
Part of ISSN: 1365-2125
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David Busse
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