Massimo Locati graduated summa cum laude in Medicine in 1992 from University of Milan, Italy. He was then Research Fellow in the Department of Immunology and Cell Biology at Mario Negri Institute, Milan (1992-1995) and subsequently in the Laboratory of Host Defenses, National Institutes of Health in Bethesda, Washington (1995-1996). During these years he was mainly involved in the definition of chemokine receptors signalling properties and in particular he defined the role of chemokine receptors’ signalling in HIV-1 infection. He was then Research Assistant at the University of Brescia (1998) and moved to the University of Milan in 2001, were he is now Professor of Immunology and General Pathology at the Department of Medical Biotechnologies and Translational Medicine. Since 2007 he is chief of the Leukocyte Biology Lab at the Humanitas Clinical and Reseach Center in Rozzano (Milan).
In his scientific career he has contributed to the identification of chemokine receptors and their biological role in inflammatory diseases, to the identification of atypical/decoy chemokine receptors, to the definition and molecular characterization of macrophage polarized activation (M1/M2 signatures). The lab is now focused on molecular mechanisms controlling inflammatory responses and their resolution (mechanism of action and biological relevance of atypical receptors and identification and functional characterization of inflammation-related microRNA) and on macrophage biology in tumors (from their recruitment to their polarized activation and underlying molecular mechanisms, with particular relevance to inflammation-related microRNA). On these topics he has authored over 150 peer-reviewed publications, with a total Impact Factor above 850 and 14000 citations. His present H index is 54.