Personal information

heatstroke, heat shock, heat exhaustion, heat stress, hyperthermia, sepsis, septic shock, inflammation
Saudi Arabia

Biography

I am an MD from Constantine Medical School and board equivalent in Critical Care Medicine, holder of a Habilitation a Diriger des Recherches (HDR) from Xavier Bichat Medical School, University Paris VII.

I worked as an intensivist for eight years in university hospitals in Paris before moving to the Kingdom of Saudi Arabia (KSA). I joined King Faisal Hospital and Research Center, Riyadh, Saudi Arabia, in 1986. I occupied several positions, including head of the medical-surgical intensive care unit, principal scientist, and Chair of the department of comparative medicine. I joined King Abdullah International Medical Research Center in 2010 to present as Chair of the Department of Experimental Medicine and consultant intensivist.

In parallel to my clinical activities, my research started in Paris and covered different aspects of critical illnesses. In Saudi Arabia, I was asked to work in Mecca during the pilgrimage in the desert climate Mecca in July 1986, where I witnessed the deaths of hundreds of patients with heatstroke in a few days. This experience has shifted my research focus to heat illnesses, particularly heat exhaustion and heatstroke. Since then, I have acquired a unique clinical experience managing patients with heat illnesses. I have also conducted translational research, including randomized clinical trials, developing a nonhuman primate heatstroke model, and testing novel therapeutic targets. I have also performed systematic reviews and metanalysis that served as the framework for the WHO's current preventive public health strategy. The findings of this research were recapitulated in a review paper in the New England Journal of Medicine in 2002 and, more recently, in Nature Reviews Primer diseases in 2022. Stanford University has ranked me in the top 2% of the most cited researcher in 2021.

I have two patents by the United States Patent and Trademark Office (USPTO). This includes an "Artificial hypothalamus for body temperature regulation" in 2017 and a "Method of regulating body temperature." A proof of concept (POC) carried out in collaboration with a local industrial partner demonstrated that the proposed device (artificial hypothalamus) and a next-generation cooling bed based on these patents are feasible, with the realistic prospect of becoming an innovative medical device.
I was invited by the WHO European Center for Environment and Health in 2005 to participate in the Euro-heat project, which aimed to protect the population from heat waves. I chaired the work package on "Evidence-based framework for health interventions in a heatwave and medical treatment practice." I was commissioned to write the preventive and therapeutic strategies for facing extreme heat. I was also among the group of experts contributing to the "Global Research Priorities to Protect Health from Climate Changes" organized by WHO in Madrid in 2008.

I am currently the Principal Investigator of a funded megaproject using a multifaceted approach: a) a system biology approach, including genomics, epigenomics, transcriptomics, proteomics, and metabolomics, to identify specific signatures for the diagnosis or prognosis of heatstroke. b) A genome-wide association study to investigate the genetic determinants of heatstroke that could influence (increase susceptibility or tolerance) heatstroke biology. c) A research on epigenetics and gene–environmental heat interactions that would enhance individual risk prediction to extreme heat. These investigations would provide more precise data for targeted prevention and better protection of population health during exposure to extreme heat.

Activities

Employment (2)

King Abdullah International Medical Research Center: Riyadh, SA

2010 to present | Chairman and Senior Research Scientist (Experimental Medicine Department)
Employment
Source: Self-asserted source
abderrezak BOUCHAMA

King Abdulaziz Medical City: Riyadh, Al Riyadh Province, SA

2010 to present | Consultant Intensivist (Intensive Care Department)
Employment
Source: Self-asserted source
abderrezak BOUCHAMA

Education and qualifications (3)

Université Paris VII: Paris, FR

2000 | Habilitation a Diriger des Recherches (HDR)
Education
Source: Self-asserted source
abderrezak BOUCHAMA

University of Paris VII: Paris, FR

1982 | Critical Care Medicine (Certificat d’université en Réanimation Médicale C.U.R.M: equivalent of the American board)
Education
Source: Self-asserted source
abderrezak BOUCHAMA

Constantine Medical School: Constantine, DZ

1971 to 1977 | Medicine
Education
Source: Self-asserted source
abderrezak BOUCHAMA

Works (50 of 132)

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Beyond heatwaves: A nuanced view of temperature-related mortality

Temperature
2024-07-02 | Journal article
Contributors: Abderrezak Bouchama; Toby Mündel; Orlando Laitano
Source: check_circle
Crossref

Insights into pathophysiology and therapeutic strategies for heat stroke: Lessons from a baboon model

Experimental Physiology
2024-04 | Journal article
Contributors: Mashan Abdullah; Salleh Ehaideb; George Roberts; Abderrezak Bouchama
Source: check_circle
Crossref

Transcriptome Changes and Metabolic Outcomes After Bariatric Surgery in Adults With Obesity and Type 2 Diabetes

Journal of the Endocrine Society
2023-12-01 | Journal article
Contributors: Mamoon Rashid; Ali Al Qarni; Saeed Al Mahri; Sameer Mohammad; Altaf Khan; Mashan L Abdullah; Cynthia Lehe; Reem Al Amoudi; Omar Aldibasi; Abderrezak Bouchama
Source: check_circle
Crossref

Whole genome transcriptomic reveals heat stroke molecular signatures in humans

The Journal of Physiology
2023-06 | Journal article
Contributors: Abderrezak Bouchama; Mamoon Rashid; Shuja Shafi Malik; Saeed Al Mahri; Yara Yassin; Mashan Abdullah; Nour Abdulmalek; Fuad Maashi; Abdulaziz Mashi; Altaf Khan et al.
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Crossref

Association of Ambient Temperature with Mortality in Resident and Multiethnic Transient Populations in a Desert Climate, 2006–2014

Environmental Health Perspectives
2023-04 | Journal article
Contributors: Saber Yezli; Altaf H. Khan; Yara M. Yassin; Anas A. Khan; Badriah M. Alotaibi; Abderrezak Bouchama
Source: check_circle
Crossref

Classic heat stroke in a desert climate: A systematic review of 2632 cases

Journal of Internal Medicine
2023-04-03 | Journal article
Part of ISSN: 0954-6820
Part of ISSN: 1365-2796
Contributors: Saber Yezli; Yara Yassin; Sujoud Ghallab; Mashan Abdullah; Bisher Abuyassin; Ramesh Vishwakarma; Abderrezak Bouchama
Source: Self-asserted source
abderrezak BOUCHAMA

Biomarkers of heatstroke‐induced organ injury and repair

Experimental Physiology
2022-10 | Journal article
Contributors: Zachary J. Schlader; Michael S. Davis; Abderrezak Bouchama
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Crossref

Heat-Induced Proteotoxic Stress Response in Placenta-Derived Stem Cells (PDSCs) Is Mediated through HSPA1A and HSPA1B with a Potential Higher Role for HSPA1B

Current Issues in Molecular Biology
2022-10-10 | Journal article
Contributors: Bothina Mohammed Alharbi; Aisha Bugshan; Azhaar Almozel; Reem Alenzi; Abderrezak Bouchama; Tanvir Khatlani; Sameer Mohammad; Shuja Shafi Malik
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Crossref
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Classic and exertional heatstroke

Nature Reviews Disease Primers
2022-02-03 | Journal article
Contributors: Abderrezak Bouchama; Bisher Abuyassin; Cynthia Lehe; Orlando Laitano; Ollie Jay; Francis G. O’Connor; Lisa R. Leon
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Crossref

Favipiravir and Hydroxychloroquine Combination Therapy in Patients with Moderate to Severe COVID-19 (FACCT Trial): An Open-Label, Multicenter, Randomized, Controlled Trial

Infectious Diseases and Therapy
2021-12 | Journal article
Part of ISSN: 2193-8229
Part of ISSN: 2193-6382
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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Obesity and COVID-19: what makes obese host so vulnerable?

Immunity & Ageing
2021-12 | Journal article
Part of ISSN: 1742-4933
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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Interferon-induced transmembrane protein-3 genetic variant rs12252 is associated with COVID-19 mortality

Genomics
2021-07 | Journal article
Part of ISSN: 0888-7543
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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A Trial of Favipiravir and Hydroxychloroquine combination in Adults Hospitalized with moderate and severe Covid-19: A structured summary of a study protocol for a randomised controlled trial

Trials
2020-12 | Journal article
Part of ISSN: 1745-6215
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review

Critical Care
2020-12 | Journal article
Contributors: Salleh N. Ehaideb; Mashan L. Abdullah; Bisher Abuyassin; Abderrezak Bouchama
Source: check_circle
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SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence

Pathogens
2020-08-20 | Journal article
Contributors: Sameer Mohammad; Abderrezak Bouchama; Bothina Mohammad Alharbi; Mamoon Rashid; Tanveer Saleem Khatlani; Nusaibah S. Gaber; Shuja Shafi Malik
Source: check_circle
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A systematic review uncovers a wide-gap between COVID-19 in humans and animal models

2020-07-17 | Other
Contributors: Salleh N. Ehaideb; Mashan L. Abdullah; Bisher Abuyassin; Abderrezak Bouchama
Source: check_circle
Crossref
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Leptin, Ghrelin, and Leptin/Ghrelin Ratio in Critically Ill Patients

Nutrients
2019-12-21 | Journal article
Part of ISSN: 2072-6643
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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Summer Hajj pilgrimage in the era of global warming: a call for vigilance and better understanding of the risks

Journal of Travel Medicine
2019-10-14 | Journal article
Part of ISSN: 1708-8305
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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Oxidative stress, caloric intake and outcomes of critically ill patients

Clinical Nutrition ESPEN
2019-02 | Journal article
Part of ISSN: 2405-4577
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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Permissive underfeeding, cytokine profiles and outcomes in critically ill patients

PLOS ONE
2019-01-07 | Journal article
Part of ISSN: 1932-6203
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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Heatstroke

Thermoregulation: From Basic Neuroscience to Clinical Neurology, Part II
2018 | Book chapter
Part of ISBN: 9780444640741
Part of ISSN: 0072-9752
Source: Self-asserted source
abderrezak BOUCHAMA
grade
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A Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress

Scientific Reports
2017-08-25 | Journal article
Contributors: Abderrezak Bouchama; Mohammad Azhar Aziz; Saeed Al Mahri; Musa Nur Gabere; Meshan Al Dlamy; Sameer Mohammad; Mashael Al Abbad; Mohamed Hussein
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Crossref
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Middle East Respiratory Syndrome

New England Journal of Medicine
2017-02-09 | Journal article
Contributors: Yaseen M. Arabi; Hanan H. Balkhy; Frederick G. Hayden; Abderrezak Bouchama; Thomas Luke; J. Kenneth Baillie; Awad Al-Omari; Ali H. Hajeer; Mikiko Senga; Mark R. Denison et al.
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search
grade
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Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia

Emerging Infectious Diseases
2016-09 | Journal article
Contributors: Yaseen M. Arabi; Ali H. Hajeer; Thomas Luke; Kanakatte Raviprakash; Hanan Balkhy; Sameera Johani; Abdulaziz Al-Dawood; Saad Al-Qahtani; Awad Al-Omari; Fahad Al-Hameed et al.
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search
grade
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Pathophysiology and management of hyperthermia

Oxford Medicine Online
2016-04 | Book
Contributors: Abderrezak Bouchama
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search

Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol.

2015 | Journal article
Contributors: Arabi Y; Balkhy H; Hajeer AH; Bouchama A; Hayden FG; Al-Omari A; Al-Hameed FM; Taha Y; Shindo N; Whitehead J et al.
Source: Self-asserted source
abderrezak BOUCHAMA via Europe PubMed Central
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Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV).

2015-08 | Journal article
Contributors: Arabi YM; Harthi A; Hussein J; Bouchama A; Johani S; Hajeer AH; Saeed BT; Wahbi A; Saedy A; AlDabbagh T et al.
Source: Self-asserted source
abderrezak BOUCHAMA via Europe PubMed Central
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Heat stroke.

2015-04 | Journal article
Contributors: Leon LR; Bouchama A
Source: Self-asserted source
abderrezak BOUCHAMA via Europe PubMed Central
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Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study.

2013 | Journal article
Contributors: Arabi YM; Dara SI; Tamim HM; Rishu AH; Bouchama A; Khedr MK; Feinstein D; Parrillo JE; Wood KE; Keenan SP et al.
Source: Self-asserted source
abderrezak BOUCHAMA via Europe PubMed Central
grade
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Non-communicable health risks during mass gatherings

The Lancet Infectious Diseases
2012 | Journal article
DOI:

10.1016/S1473-3099(11)70293-6

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
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Pathogenetic mechanisms of heatstroke and novel therapies

Critical Care
2012 | Journal article
Contributors: Abderrezak Bouchama
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search

Pathogenetic mechanisms of heatstroke and novel therapies.

2012 | Journal article
Contributors: Bouchama A
Source: Self-asserted source
abderrezak BOUCHAMA via Europe PubMed Central

Tissue factor/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon

Critical Care Medicine
2012 | Journal article
DOI:

10.1097/CCM.0b013e3182387bef

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Toll-Like Receptor 4 and High-Mobility Group Box 1 Are Critical Mediators of Tissue Injury and Survival in a Mouse Model for Heatstroke

PLoS ONE
2012 | Journal article
DOI:

10.1371/journal.pone.0044100

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Presentation And Outcome Of Diabetic Patients Admitted With Septic Shock

B23. OUTCOMES, HEALTH SERVICES AND PATIENT-CENTERED RESEARCH IN THE INTENSIVE CARE UNIT
2012-05 | Conference paper
Contributors: Hasan M. Al-Dorzi; Hani Tamim; Abderrezak Bouchama; Anand Kumar; Yaseen M. Arabi
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search

Toll-Like Receptor 4 And High-Mobility Group Box 1 Are Critical Mediators Of Tissue Injury And Survival In A Mouse Model For Heatstroke

C31. REGULATION OF LUNG INFLAMMATION
2012-05 | Conference paper
Contributors: Abderrezak Bouchama; Tahar Uzzaman; engin baturcam; Abdelmoneim Eldali; Mohammed Dehbi
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search

SRAGE in diabetic and non-diabetic critically ill patients: Effects of intensive insulin therapy

Critical Care
2011 | Journal article
DOI:

10.1186/cc10420

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Diabetes Mellitus Is Associated With Reduced Mortality In Critically Ill Patients

B49. INTENSIVE CARE UNIT MANAGEMENT
2011-05 | Conference paper
Contributors: Hasan M. Al-Dorzi; Abderrezak Bouchama; Hani Tamim; Amer Zwein; Hesham AbdalRazik; Haytham Tlayjeh; Yaseen Arabi
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search

Differential Release And Intensive Insulin Therapy Effect On Srage In Hyperglycemic Diabetic And Non-Diabetic Patients Admitted To ICU

B49. INTENSIVE CARE UNIT MANAGEMENT
2011-05 | Conference paper
Contributors: Yaseen Arabi; Mohammed Dehbi; Asgar Rishu; Engin Baturcam; Salim Kahoul; Riette Brits; Brintha Naidu; Abderrezak Bouchama
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search

Hsp-72, a candidate prognostic indicator of heatstroke

Cell Stress and Chaperones
2010 | Journal article
DOI:

10.1007/s12192-010-0172-3

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
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Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke a study in baboon model

Arteriosclerosis, Thrombosis, and Vascular Biology
2008 | Journal article
DOI:

10.1161/ATVBAHA.107.158709

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Recombinant activated protein c attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke

Arteriosclerosis, Thrombosis, and Vascular Biology
2008 | Journal article
DOI:

10.1161/ATVBAHA.107.161737

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Respiratory Arrest: A Complication of Arnold-Chiari Malformation in Adults

European Neurology
2008-02 | Journal article
Contributors: Salah Omer; M. Zuheir Al-Kawi; Saeed Bohlega; Abderrezak Bouchama; Donald Mclean
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search
grade
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Cooling and hemodynamic management in heatstroke: Practical recommendations

Critical Care
2007 | Journal article
DOI:

10.1186/cc5910

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Cooling and hemodynamic management in heatstroke: practical recommendations.

Critical care (London, England)
2007 | Journal article
Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier

Glucocorticoids do not protect against the lethal effects of experimental heatstroke in baboons

Shock
2007 | Journal article
DOI:

10.1097/01.shk.0000246903.40142.aa

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Prognostic factors in heat wave-related deaths: A meta-analysis

Archives of Internal Medicine
2007 | Journal article
DOI:

10.1001/archinte.167.20.ira70009

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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Heatstroke: Facing the threat

Critical Care Medicine
2006 | Journal article
DOI:

10.1097/01.CCM.0000208354.85490.45

Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
grade
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DEXAMETHASONE DOES NOT PROTECT AGAINST THE LETHAL EFFECTS OF INDUCED HEATSTROKE IN BABOONS.

Critical Care Medicine
2005 | Journal article
Contributors: Abderrezak Bouchama; Aaron Kwaasi; Falah Al Mohanna; Abdelmoniem Eldali; Raafat El-Sayed; Abdelghani Tbakhi; Ali Al Zahrani; George Roberts
Source: Self-asserted source
abderrezak BOUCHAMA via Crossref Metadata Search

Erratum: Experimental heatstroke in Baboon: Analysis of the systemic inflammatory response (Shock (2005) 24, 4 (332-335))

Shock
2005 | Journal article
Source: Self-asserted source
abderrezak BOUCHAMA via Scopus - Elsevier
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