Rui Henrique was born in Porto in 1968 and received his M.D. from the Abel Salazar Institute of Biomedical Sciences of the University of Porto (ICBAS-UP) in 1992.
After completing the general medical internship at Hospital Geral de Sto. António – Porto (1993-1994), he became resident in Anatomic Pathology at the Portuguese Oncology Institute – Porto (IPO-Porto), under the supervision of Prof. Carlos Lopes. During this period, he subspecialized in Hematopathology following a 3-month training period at the University Hospitals in Leuven, Belgium, under the supervision of Prof. Christiane De Wolf-Peeters.
He remained affiliated with IPO-Porto as an attending pathologist and became Director of the Department of Pathology in 2006. In the same year he received his Ph.D. in Medical Sciences (Molecular Pathology) at ICBAS-UP, with a thesis on epigenetic heterogeneity of prostate cancer and precursor lesions, which was in part performed at the Johns Hopkins University, Baltimore, MD, USA, under the supervision of Prof. David Sidransky. In 2011, he obtained the academical title of “Aggregate” in Pathology and Molecular Genetics from ICBAS-UP.
As invited Full Professor at the Department of Pathology and Molecular Immunology of ICBAS-UP, he coordinates and lectures the curricular units of Pathology and Anatomic Pathology to the integrated master degree in Medicine, in addition to the coordination of the curricular units of Oncobiology (M.Sc. course in Biochemistry), Special Oncology (M.Sc. in Oncology) and Pathology of Neoplasia (Ph.D. course in Pathology and Molecular Genetics)
His diagnostic and research interests are focused mainly in Hematopathology and Uropathology, and are devoted to the understanding of the role of epigenetic alterations in prostate, bladder and kidney carcinogenesis, as well as the development of novel cancer biomarkers based on the epigenetic and genetic characterization of tumors.