Philip R Holland (0000-0003-3345-4853)

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Migraine is the most disabling disorder globally in the under 50's and as such sufferers face a severe unmet need for a greater understanding and treatments to lighten their burden. My passion is to act on both these fronts using my scientific background developed during my PhD with Prof. Goadsby in University College London, through my postdoctoral work at the University of California San Francisco and finally the University of Edinburgh. I now lead a team of researchers at Headache Group, King’s College London with the fundamental goal of developing an improved understanding the basic biology of migraine and other primary headaches. Our projects are currently funded by the Medical Research Council, Migraine Trust, Wellcome Trust and the European Research Council and we openly thank them for providing the funding that is so desperately needed to make a difference.

When not undertaking research and teaching I am a committee member of the British Association for the Study of Headache, on the organising committee of the Migraine Trust International Congress, an associate editor for Cephalalgia and strive to increase the public awareness of migraine.

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King's College London: London, GB

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Philip R Holland

https://orcid.org/0000-0003-3345-4853

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Biography

Activities

Employment (2)

King's College London: London, GB

King's College London: London, GB

Education and qualifications (3)

King's College London: London, London, GB

University College London: London, London, GB

University of Glasgow: Glasgow, Glasgow, GB

Professional activities (3)

University College London: London, London, GB

British Association for the Study of Headache: Hull, GB

International Headache Society: London, London, GB

Funding (2)

The role of circadian mechanisms in migraine-related pain

Characterisation of neurotransmitter content of trigeminovascular nociceptive afferents/

Works (50 of 78)

Orexins and primary headaches: an overview of the neurobiology and clinical impact

Sexually dimorphic effects of Amylin 1 receptor activation in trigeminovascular neurons

Investigating the relationship between sleep and migraine in a global sample

A role for thalamic projection GABAergic neurons in circadian responses to light

Establishing Causality in the Relationship between Sleep and Migraine in a Global Sample: A Bayesian Approach

A role for thalamic projection GABAergic neurons in circadian responses to light

A Role for Thalamic Projection GABAergic Neurons in Circadian Responses to Light

Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes

The selective 5‐HT1F receptor agonist lasmiditan inhibits trigeminal nociceptive processing: Implications for migraine and cluster headache

Subjective Sleep Quality and Sleep Architecture in Patients With Migraine

Subjective sleep quality and objective sleep physiology in migraineurs: a meta-analysis

Differential actions of indomethacin: clinical relevance in headache

Medication overuse headache: Divergent effects of new acute antimigraine drugs

Rapid uptake of sumatriptan into the brain: An ongoing question of blood-brain barrier permeability

Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives

Differential medication overuse risk of novel anti-migraine therapeutics

Acid‐sensing ion channel 3 blockade inhibits durovascular and nitric oxide‐mediated trigeminal pain

Brain structure and function related to headache

An Update

Animal models of migraine and experimental techniques used to examine trigeminal sensory processing

Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity

Cilostazol as a chemically induced preclinical model of migraine

Divergent influences of the locus coeruleus on migraine pathophysiology

Foreword: The CGRP Pathway and Migraine Prevention: Reducing the Burden of Disease.

Targeted CGRP Small Molecule Antagonists for Acute Migraine Therapy.

Migraine Therapy

PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache.

The role of the brainstem in migraine: Potential brainstem effects of CGRP and CGRP receptor activation in animal models.

Neurobiological basis of migraine

Biology of Neuropeptides: Orexinergic Involvement in Primary Headache Disorders

Chronic cerebral hypoperfusion alters amyloid-β peptide pools leading to cerebral amyloid angiopathy, microinfarcts and haemorrhages in Tg-SwDI mice.

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease.

Neuroendocrine signaling modulates specific neural networks relevant to migraine

Pathophysiology of Migraine

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators.

Current and novel insights into the neurophysiology of migraine and its implications for therapeutics

Transcranial magnetic stimulation and potential cortical and trigeminothalamic mechanisms in migraine

Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease

Modulation of nociceptive dural input to the trigeminocervical complex through Gluk1 kainate receptors

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

Headache and sleep

Differential trigeminovascular nociceptive responses in the thalamus in the familial hemiplegic migraine 1 knock-in mouse

Migraine Pathophysiology

Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion

Controlled hypertension induces cerebrovascular and gene alterations in Cyp1a1-Ren2 transgenic rats

Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and "Triptan" Receptors

Pearls and pitfalls in experimental in vivo models of migraine

A translational in vivo model of trigeminal autonomic cephalalgias

Acid-sensing ion channel 1

Axon-glial disruption: The link between vascular disease and Alzheimer's disease?

Peer review (4 reviews for 2 publications/grants)