As developments borne in basic research are translated directly into therapies applied in the clinic, the long-term objectives of my work are to develop therapies aimed at combating blood-borne disease. I have a broad background in molecular and cellular biology, with specific training in key research areas of my developed platform. During my graduate studies at Oxford University and my postdoctoral training at Harvard Medical School, I became an expert in hematopoiesis, blood cell development, hematopoietic stem cell biology, transcription factor regulation, viral gene transfer, and bone marrow transplantation. I am also well-versed in murine and human embryonic stem cell (ESC) technologies and in the generation, manipulation, culture, and directed differentiation of both ESC and the recently discovered iPSC. I have a solid publication record in high profile journals including recent articles focused upon the development and characterization of a novel, regulatable lentiviral gene transfer system, the highly efficient production of iPSC using a single stem cell cassette, hematopoietic progenitor and stem cell biology, as well as in the production and genetic modification many iPSC-derived cell lineages. In summary, I have a demonstrated record of successful and productive research projects in an extraordinarily competitive field.