Cycloheximide treatment to identify components of the transitional transcriptome in PACAP-induced PC12 cell differentiation
Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide
Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects
Involvement of stathmin 1 in the neurotrophic effects of PACAP in PC12 cells
Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure
Neurosteroid Biosynthesis in the Brain of Amphibians
Neurotrophic Activity of Pituitary Adenylate Cyclase-Activating Polypeptidea
Novel stable PACAP analogs with potent activity towards the PAC1 receptor
Octadecaneuropeptide, ODN, protects cerebellar granule neurons against oxidative stress-induced apoptosis
PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression
PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action
Peroxiredoxin 2 is Involved in the Neuroprotective Effects of PACAP in Cultured Cerebellar Granule Neurons
Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP
Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis
Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Apoptosis
Protective effect of the octadecaneuropeptide on hydrogen peroxide-induced oxidative stress and cell death in cultured rat astrocytes
Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide
Regulation of Neurosteroid Biosynthesis by Neurotransmitters and Neuropeptides
The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways
Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth.
P2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy.
Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum.
Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome.
Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function.
Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes.
Enteral delivery of proteins enhances the expression of proteins involved in the cytoskeleton and protein biosynthesis in human duodenal mucosa.
Structural and functional analysis of tunneling nanotubes (TnTs) using gCW STED and gconfocal approaches.
Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats.
Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model.
Ex vivo imaging of postnatal cerebellar granule cell migration using confocal macroscopy.
Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells.
PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF.
The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis.
Glutamine enema regulates colonic ubiquitinated proteins but not proteasome activities during TNBS-induced colitis leading to increased mitochondrial activity.
Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice.
Detection, characterization and biological activities of [bisphospho-thr3,9]ODN, an endogenous molecular form of ODN released by astrocytes.
International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function.
A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing m2 microglia/macrophage polarization.
Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants.
Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders.
Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies.
Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.
The role of calcium and cyclic nucleotide signaling in cerebellar granule cell migration under normal and pathological conditions.
Induction of serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal.
Extracts from medicinal plants inhibit cancer cell proliferation, induce apoptosis in ovary, lung and neuronal cancer cell lines.
Biochemical characterization of a Caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis.
Cortical-layer-specific effects of PACAP and tPA on interneuron migration during post-natal development of the cerebellum.
Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa.
Comparison of protein-extraction methods for gills of the shore crab, Carcinus maenas (L.), and application to 2DE.
Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation.
Activation of PAC1 Receptors in Rat Cerebellar Granule Cells Stimulates Both Calcium Mobilization from Intracellular Stores and Calcium Influx through N-Type Calcium Channels.
Spatio-temporal characterization of the pleiotrophinergic system in mouse cerebellum: evidence for its key role during ontogenesis.
The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway.
Assessment of cyto-protective, antiproliferative and antioxidant potential of a medicinal plant Jatropha podagrica
The stimulatory effect of the octadecaneuropeptide ODN on astroglial antioxidant enzyme systems is mediated through a GPCR.
An enteral leucine supply modulates human duodenal mucosal proteome and decreases the expression of enzymes involved in fatty acid beta-oxidation.
The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism.
Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-β3-pseudopeptide agonist.
Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum.
Cardiotoxin-I: an unexpectedly potent insulinotropic agent.
Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.
Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency.
Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling.
High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters.
Gastric inhibitory polypeptide and its receptor are expressed in the central nervous system and support neuronal survival.
Impact of toxicant exposure on the proteomic response to intertidal condition in Mytilus edulis.
Effects of an enteral glucose supply on protein synthesis, proteolytic pathways, and proteome in human duodenal mucosa.
Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug.
Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP.
Characterization of some neurotrophic activities of PACAP and development of new analogs for in vivo treatments.
Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum.
Biofilm-induced modifications in the proteome of Pseudomonas aeruginosa planktonic cells.
Human duodenal proteome modulations by glutamine and antioxidants.
Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.
Role of PACAP in controlling granule cell migration.
Paradoxical effect of ethanol on potassium channel currents and cell survival in cerebellar granule neurons.
Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor.
NOV/CCN3 promotes maturation of cerebellar granule neuron precursors.
Distribution and functional characterization of pituitary adenylate cyclase-activating polypeptide receptors in the brain of non-human primates.
Pituitary adenylate cyclase-activating polypeptide: focus on structure-activity relationships of a neuroprotective Peptide.
Discovery of pituitary adenylate cyclase-activating polypeptide-regulated genes through microarray analyses in cell culture and in vivo.
Latent fluorophores based on a self-immolative linker strategy and suitable for protease sensing.
Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum.
PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: involvement of the mitochondrial apoptotic pathway.
Interactions of PACAP and ceramides in the control of granule cell apoptosis during cerebellar development.
Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases.
Biological and structural analysis of truncated analogs of PACAP27.
A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells.
Outer-membrane proteomic maps and surface-exposed proteins of Legionella pneumophila using cellular fractionation and fluorescent labelling.
Molecular, cellular, and functional characterizations of pituitary adenylate cyclase-activating polypeptide and its receptors in the cerebellum of New and Old World monkeys.
Neurotrophic effects of PACAP in the cerebellar cortex.
The neuropeptide pituitary adenylate cyclase-activating polypeptide exerts anti-apoptotic and differentiating effects during neurogenesis: focus on cerebellar granule neurones and embryonic stem cells.
Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide.
Neuroprotection by endogenous and exogenous PACAP following stroke.
Ontogeny of PACAP receptors in the human cerebellum: perspectives of therapeutic applications.
Foreword to special issue: molecular and cellular mechanisms of VIP, PACAP and secretin signaling applied to systems biology.
The delayed rectifier channel current IK plays a key role in the control of programmed cell death by PACAP and ethanol in cerebellar granule neurons.
PACAP and VIP promote initiation of electrophysiological activity in differentiating embryonic stem cells.
PACAP and ceramides exert opposite effects on migration, neurite outgrowth, and cytoskeleton remodeling.
PACAP stimulates biosynthesis and release of endozepines from rat astrocytes.
Identification of proteins regulated by PACAP in PC12 cells by 2D gel electrophoresis coupled to mass spectrometry.
Localization and characterization of pituitary adenylate cyclase-activating polypeptide receptors in the human cerebellum during development.
N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells.
[Effects of PACAP and C2-ceramide on motility of cerebellar granule neurons: the fastest is not the farthest].
Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult.
Pituitary adenylate cyclase-activating polypeptide prevents the effects of ceramides on migration, neurite outgrowth, and cytoskeleton remodeling.
Pituitary adenylate cyclase-activating polypeptide inhibits caspase-3 activity but does not protect cerebellar granule neurons against beta-amyloid (25-35)-induced apoptosis.
Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells.
Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death.
PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP.
Regulators of cerebellar granule cell development act through specific signaling pathways.
Pituitary adenylate cyclase-activating polypeptide prevents C2-ceramide-induced apoptosis of cerebellar granule cells.
Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates endozepine release from cultured rat astrocytes via a PKA-dependent mechanism.
Analysis of the PC12 cell transcriptome after differentiation with pituitary adenylate cyclase-activating polypeptide (PACAP).
Fast-breaking results on the PACAP/VIP/secretin peptide family in chromaffin cells.
PC12 cells as a model to study the neurotrophic activities of PACAP.
PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis.
Signaling pathways for PC12 cell differentiation: making the right connections.
Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death.
Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN. Design of a potent endozepine antagonist.
Immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the brain of the African lungfish Protopterus annectens.
gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus.
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32.
Comparative distribution of pituitary adenylate cyclase-activating polypeptide (PACAP) binding sites and PACAP receptor mRNAs in the rat brain during development.
Expression of a complete and functional complement system by human neuronal cells in vitro.
Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions.
Distribution of PACAP receptor mRNAs and PACAP binding sites in the rat brain during development.
PACAP acts as a neurotrophic factor during histogenesis of the rat cerebellar cortex.
Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development.
[Pituitary adenylate cyclase-activating polypeptide]
The neurotrophic activity of PACAP on rat cerebellar granule cells is associated with activation of the protein kinase A pathway and c-fos gene expression.
Pituitary adenylate cyclase-activating polypeptide stimulates both c-fos gene expression and cell survival in rat cerebellar granule neurons through activation of the protein kinase A pathway.
Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts.
Ontogeny of PACAP and PACAP receptors in the rat brain: role of PACAP in the cerebellum during development.
Melanotropes of the lizard, Anolis carolinensis, lack N-acetylating mechanisms for both alpha-melanocyte-stimulating hormone and beta-endorphin.