Barbara Seaton

ORCID iD
orcid.org/0000-0003-4654-7709
  • Websites
Physiology & Biophysics Faculty

Sources:
Boston University (2014-07-21)

BU Profiles

Sources:
Boston University (2014-07-21)

  • Email
seatonba@bu.edu

Sources:
0000-0003-4654-7709 (2013-09-23)

Biography

Dr. Seaton is an x-ray crystallographer whose long-term research interests concern interactions between mammalian proteins and biomembranes or other large assemblies such as viruses. The current focus of the lab is on the lung surfactant proteins A and D and their roles in innate host defense against inhaled pathogens including seasonal and pandemic strains of influenza A virus. These surfactant proteins are C-type lectins that can recognize sugars and other signature components on microbial surfaces, and can initiate events leading to pathogen neutralization. The Seaton lab uses x-ray crystallography, molecular modeling, and various biochemical and biophysical methods to understand the nature of these interactions at the highest resolution possible.
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