Barbara Seaton

ORCID iD
https://orcid.org/0000-0003-4654-7709
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BU Profiles

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Boston University (2014-07-21)

Physiology & Biophysics Faculty

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Boston University (2014-07-21)

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0000-0003-4654-7709 (2013-09-23)

Biography

Dr. Seaton is an x-ray crystallographer whose long-term research interests concern interactions between mammalian proteins and biomembranes or other large assemblies such as viruses. The current focus of the lab is on the lung surfactant proteins A and D and their roles in innate host defense against inhaled pathogens including seasonal and pandemic strains of influenza A virus. These surfactant proteins are C-type lectins that can recognize sugars and other signature components on microbial surfaces, and can initiate events leading to pathogen neutralization. The Seaton lab uses x-ray crystallography, molecular modeling, and various biochemical and biophysical methods to understand the nature of these interactions at the highest resolution possible.
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