Biography

Dr. Seaton is an x-ray crystallographer whose long-term research interests concern interactions between mammalian proteins and biomembranes or other large assemblies such as viruses. The current focus of the lab is on the lung surfactant proteins A and D and their roles in innate host defense against inhaled pathogens including seasonal and pandemic strains of influenza A virus. These surfactant proteins are C-type lectins that can recognize sugars and other signature components on microbial surfaces, and can initiate events leading to pathogen neutralization. The Seaton lab uses x-ray crystallography, molecular modeling, and various biochemical and biophysical methods to understand the nature of these interactions at the highest resolution possible.

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