Personal information

Emails & domains

Verified email domains

Websites & social links

ruedalab.org

Other IDs

ResearcherID: F-9065-2014

Activities

Collapse all

Employment (4)

Imperial College London: London, London, GB

2012-10 to present | Professor (Medicine)
Employment
Source: Self-asserted source
David Rueda

Wayne State University: Detroit, MI, US

2011-08 to 2012-09 | Associate Professor (Chemistry)
Employment
Source: Self-asserted source
David Rueda

Wayne State University: Detroit, MI, US

2005-08 to 2011-08 | Assistant Professor (Chemistry)
Employment
Source: Self-asserted source
David Rueda

University of Michigan: Ann Arbor, MI, US

2001-08-01 to 2005-08-14 | Postodoctoral Fellow (Chemistry)
Employment
Source: Self-asserted source
David Rueda

Education and qualifications (2)

EPFL: Lausanne, Vaud, CH

1997-07 to 2001-06 | D.Sc. (Chemistry)
Education
Source: Self-asserted source
David Rueda

EPFL: Lausanne, Vaud, CH

1992-10 to 1997-04 | Dipl. Chem. Eng. (Chemistry and Chemical Engineering)
Education
Source: Self-asserted source
David Rueda

Funding (4)

Single Molecule Imaging

Source: Self-asserted source
David Rueda via DimensionsWizard

CONFERENCE: 2010 Rustbelt RNA Meeting to be held October 22-23, 2010 in Cleveland OH

2010-07-01 to 2011-06-30 | Grant
National Science Foundation - Directorate for Biological Sciences (n/a, US)
URL: https://grants.uberresearch.com/100000076/1027593/CONFERENCE-2010-Rustbelt-RNA-Meeting-to-be-held-October-22-23-2010-in-Cleveland-OH
GRANT_NUMBER: grant.1027593
Source: Self-asserted source
David Rueda via DimensionsWizard

CAREER: RNA Folding Dynamics by Single Molecule Temperature Jump Kinetics

2008-04-15 to 2013-03-31 | Grant
National Science Foundation - Directorate for Biological Sciences (n/a, US)
URL: https://grants.uberresearch.com/100000076/0747285/CAREER-RNA-Folding-Dynamics-by-Single-Molecule-Temperature-Jump-Kinetics
GRANT_NUMBER: grant.0747285
Source: Self-asserted source
David Rueda via DimensionsWizard

Pliage et fonction du ribozyme delta par spectroscopie de fluorescence.

2001-07-01 to 2002-06-30 | Grant
Swiss National Science Foundation (Berne, CH)
URL: https://grants.uberresearch.com/100008367/65494/Pliage-et-fonction-du-ribozyme-delta-par-spectroscopie-de-fluorescence
GRANT_NUMBER: grant.65494
Source: Self-asserted source
David Rueda via DimensionsWizard

Works (36)

Precise intracellular uptake and endosomal release of diverse functional mRNA payloads via glutathione-responsive nanogels

Materials Today Bio
2025-02 | Journal article
DOI: 10.1016/j.mtbio.2024.101425
Contributors: Rupali Dabas; Naveenan Navaratnam; Haruki Iino; Saidbakhrom Saidjalolov; Stefan Matile; David Carling; David S. Rueda; Nazila Kamaly
Source: check_circle
Crossref

Nucleosome flipping drives kinetic proofreading and processivity by SWR1

Nature
2024-12-05 | Journal article
DOI: 10.1038/s41586-024-08152-y
Contributors: Paul Girvan; Adam S. B. Jalal; Elizabeth A. McCormack; Michael T. Skehan; Carol L. Knight; Dale B. Wigley; David S. Rueda
Source: check_circle
Crossref

Herpes simplex virus type 1 origin binding protein UL9 tethers and loops origin- and non-origin-DNA intra- and intermolecularly

2024-10-30 | Preprint
DOI: 10.1101/2024.10.30.621104
Contributors: Anita F. Meier; Jan Vuckovic; Paul Girvan; Erin Cutts; Theodora Brophy; Benjamin Ambrose; David S. Rueda
Source: check_circle
Crossref

Mechanism of BCDX2-mediated RAD51 nucleation on short ssDNA stretches and fork DNA

Nucleic Acids Research
2024-10-28 | Journal article
DOI: 10.1093/nar/gkae770
Contributors: Masaki Akita; Paul Girvan; Mario Spirek; Jiri Novacek; David Rueda; Zbynek Prokop; Lumir Krejci
Source: check_circle
Crossref

Substrate accessibility regulation of human TopIIa decatenation by cohesin

2023-11-21 | Preprint
DOI: 10.1101/2023.11.20.567865
Contributors: Erin E. Cutts; Sanjana Saravanan; Gemma L. M. Fisher; David S. Rueda; Luis Aragon
Source: check_circle
Crossref

The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle

PLOS Pathogens
2023-07-31 | Journal article
DOI: 10.1371/journal.ppat.1011494
Contributors: Aris E. N. Aristodemou; Patrick L. Green; David S. Rueda; Graham P. Taylor; Charles R. M. Bangham
Source: check_circle
Crossref

The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle

2023-01-08 | Preprint
DOI: 10.1101/2023.01.08.523159
Contributors: Aris E. N. Aristodemou; David S. Rueda; Graham P. Taylor; Charles R. M. Bangham
Source: check_circle
Crossref

Dynamic Backtracking Regulates Lesion Bypass by RNAPII

2022-12-02 | Preprint
DOI: 10.21203/rs.3.rs-2285216/v1
Contributors: George Moore; Zhong Han; Jun Xu; Juntaek Oh; Dong Wang; Jesper Svejstrup; David Rueda
Source: check_circle
Crossref

Search and processing of Holliday junctions within long DNA by junction-resolving enzymes

Nature Communications
2022-10-07 | Journal article
DOI: 10.1038/s41467-022-33503-6
Contributors: Artur P. Kaczmarczyk; Anne-Cécile Déclais; Matthew D. Newton; Simon J. Boulton; David M. J. Lilley; David S. Rueda
Source: check_circle
Crossref

Search and Processing of Holliday Junctions within Long DNA by Junction-Resolving Enzymes

2022-05-16 | Preprint
DOI: 10.21203/rs.3.rs-1619401/v1
Contributors: Artur Kaczmarczyk; Anne-Cécile Déclais; Matthew Newton; Simon Boulton; David Lilley; David Rueda
Source: check_circle
Crossref

HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51

Nature
2022-01-13 | Journal article
DOI: 10.1038/s41586-021-04261-0
Contributors: Roopesh Anand; Erika Buechelmaier; Ondrej Belan; Matthew Newton; Aleksandra Vancevska; Artur Kaczmarczyk; Tohru Takaki; David S. Rueda; Simon N. Powell; Simon J. Boulton
Source: check_circle
Crossref

Cas12a target search and cleavage on force-stretched DNA

Physical Chemistry Chemical Physics
2021 | Journal article
DOI: 10.1039/D1CP03408A
Contributors: Marialucrezia Losito; Quentin M. Smith; Matthew D. Newton; Maria Emanuela Cuomo; David S. Rueda
Source: check_circle
Crossref

Condensin compacts DNA in 15 nm steps and requires FACT for extrusion on chromatin

2021-10-05 | Preprint
DOI: 10.21203/rs.3.rs-901482/v1
Contributors: David Rueda; Swathi Sudhakar; Gemma Fisher; Pilar Gutierrez-Escribano; Jonay Garcia-Luis; Erin Cutts; Christopher Cawood; Luís Aragón
Source: check_circle
Crossref

Condensin Compacts DNA in 15nm steps and Requires FACT for Extrusion on Chromatin

2021-09-17 | Preprint
DOI: 10.1101/2021.09.15.460217
Contributors: Swathi Sudhakar; Gemma LM Fisher; Pilar Gutierrez-Escribano; Jonay Garcia-Luis; Christopher Cawood; Luis Aragon; David S Rueda
Source: check_circle
Crossref

A Minimal Load‐and‐Lock RuII Luminescent DNA Probe

Angewandte Chemie
2021-09-13 | Journal article
DOI: 10.1002/ange.202108077
Contributors: Matthew D. Newton; Simon D. Fairbanks; Jim A. Thomas; David S. Rueda
Source: check_circle
Crossref

A Minimal Load‐and‐Lock RuII Luminescent DNA Probe

Angewandte Chemie International Edition
2021-09-13 | Journal article
DOI: 10.1002/anie.202108077
Contributors: Matthew D. Newton; Simon D. Fairbanks; Jim A. Thomas; David S. Rueda
Source: check_circle
Crossref

HELQ is a dual function DSB repair enzyme modulated by RPA and RAD51

2021-07-15 | Preprint
DOI: 10.21203/rs.3.rs-583248/v1
Contributors: Simon Boulton; Roopesh Anand; Erika Buechelmaier; Ondrej Belan; Matt Newton; Aleksandra Vancevska; Artur Kaczmarczyk; David Rueda; Simon Powell
Source: check_circle
Crossref

Generation of versatile ss-dsDNA hybrid substrates for single-molecule analysis

STAR Protocols
2021-06 | Journal article
DOI: 10.1016/j.xpro.2021.100588
Contributors: Ondrej Belan; George Moore; Artur Kaczmarczyk; Matthew D. Newton; Roopesh Anand; Simon J. Boulton; David S. Rueda
Source: check_circle
Crossref

Live cell imaging of single RNA molecules with fluorogenic Mango II arrays

Nature Communications
2020-03-09 | Journal article
DOI: 10.1038/s41467-020-14932-7
Contributors: Adam D. Cawte; Peter J. Unrau; David S. Rueda
Source: check_circle
Crossref

Kinetics of HTLV-1 reactivation from latency quantified by single-molecule RNA FISH and stochastic modelling

PLOS Pathogens
2019-11-18 | Journal article
DOI: 10.1371/journal.ppat.1008164
Contributors: Michi Miura; Susan R. Ross; Supravat Dey; Saumya Ramanayake; Abhyudai Singh; David S. Rueda; Charles R. M. Bangham
Source: check_circle
Crossref

Live Cell Imaging of Single RNA Molecules with Fluorogenic Mango II Arrays

2019-11-12 | Other
DOI: 10.1101/840082
Contributors: Adam D. Cawte; Peter J. Unrau; David S. Rueda
Source: check_circle
Crossref

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Nature Communications
2019-09-13 | Journal article
DOI: 10.1038/s41467-019-12007-w
Contributors: Marcus D. Wilson; Ludovic Renault; Daniel P. Maskell; Mohamed Ghoneim; Valerie E. Pye; Andrea Nans; David S. Rueda; Peter Cherepanov; Alessandro Costa
Source: check_circle
Crossref

DNA stretching induces Cas9 off-target activity

Nature Structural & Molecular Biology
2019-03-25 | Journal article
DOI: 10.1038/s41594-019-0188-z
Contributors: Matthew D. Newton; Benjamin J. Taylor; Rosalie P. C. Driessen; Leonie Roos; Nevena Cvetesic; Shenaz Allyjaun; Boris Lenhard; Maria Emanuela Cuomo; David S. Rueda
Source: check_circle
Crossref

Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant

Physical Chemistry Chemical Physics
2018 | Journal article
DOI: 10.1039/C8CP04112A
Contributors: Hailey L. Gahlon; Alice R. Walker; G. Andrés Cisneros; Meindert H. Lamers; David S. Rueda
Source: check_circle
Crossref

Optimal molecular crowding accelerates group II intron folding and maximizes catalysis

Proceedings of the National Academy of Sciences
2018-11-20 | Journal article
DOI: 10.1073/pnas.1806685115
Contributors: Bishnu P. Paudel; Erica Fiorini; Richard Börner; Roland K. O. Sigel; David S. Rueda
Source: check_circle
Crossref

Structure and dynamics of the yeast SWR1-nucleosome complex

Science
2018-10-12 | Journal article
DOI: 10.1126/science.aat7716
Contributors: Oliver Willhoft; Mohamed Ghoneim; Chia-Liang Lin; Eugene Y. D. Chua; Martin Wilkinson; Yuriy Chaban; Rafael Ayala; Elizabeth A. McCormack; Lorraine Ocloo; David S. Rueda et al.
Source: check_circle
Crossref

Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells

Nature Communications
2018-02-13 | Journal article
DOI: 10.1038/s41467-018-02993-8
Contributors: Alexis Autour; Sunny C. Y. Jeng; Adam D. Cawte; Amir Abdolahzadeh; Angela Galli; Shanker S. S. Panchapakesan; David Rueda; Michael Ryckelynck; Peter J. Unrau
Source: check_circle
Crossref

Absence of nuclease activity in commonly used oxygen-scavenging systems

BMC Research Notes
2017-12 | Journal article
DOI: 10.1186/s13104-017-2929-6
Contributors: Hailey L. Gahlon; Paul Poudevigne-Durance; David Rueda
Source: check_circle
Crossref

Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations

Scientific Reports
2017-12-12 | Journal article
DOI: 10.1038/s41598-017-17643-0
Contributors: Pramodha S. Liyanage; Alice R. Walker; Alfonso Brenlla; G. Andrés Cisneros; Louis J. Romano; David Rueda
Source: check_circle
Crossref

Influence of DNA Lesions on Polymerase-Mediated DNA Replication at Single-Molecule Resolution

Chemical Research in Toxicology
2017-11-20 | Journal article
DOI: 10.1021/acs.chemrestox.7b00224
Contributors: Hailey L. Gahlon; Louis J. Romano; David Rueda
Source: check_circle
Crossref

Mapping the sugar dependency for rational generation of a DNA-RNA hybrid-guided Cas9 endonuclease

Nature Communications
2017-11-20 | Journal article
DOI: 10.1038/s41467-017-01732-9
Contributors: Fernando Orden Rueda; Michal Bista; Matthew D. Newton; Anne U. Goeppert; M. Emanuela Cuomo; Euan Gordon; Felix Kröner; Jon A. Read; Jonathan D. Wrigley; David Rueda et al.
Source: check_circle
Crossref

Single-cell heterogeneity and cell-cycle-related viral gene bursts in the human leukaemia virus HTLV-1

Wellcome Open Research
2017-09-22 | Journal article
DOI: 10.12688/wellcomeopenres.12469.1
Contributors: Martin R Billman; David Rueda; Charles R M Bangham
Source: check_circle
Crossref

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells

Nature Structural & Molecular Biology
2017-06-24 | Journal article
DOI: 10.1038/nsmb.3402
Contributors: Mariano Barbieri; Sheila Q Xie; Elena Torlai Triglia; Andrea M Chiariello; Simona Bianco; Inês de Santiago; Miguel R Branco; David Rueda; Mario Nicodemi; Ana Pombo
Source: check_circle
Crossref

Active and poised promoter states drive folding of the extendedHoxBlocus in mouse embryonic stem cells

2017-02-28 | Preprint
DOI: 10.1101/111773
Contributors: Mariano Barbieri; Sheila Q. Xie; Elena Torlai Triglia; Inês de Santiago; Miguel R. Branco; David Rueda; Mario Nicodemi; Ana Pombo
Source: check_circle
Crossref

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate

Nature Communications
2016-02-18 | Journal article
DOI: 10.1038/ncomms10708
Contributors: Ferdos Abid Ali; Ludovic Renault; Julian Gannon; Hailey L. Gahlon; Abhay Kotecha; Jin Chuan Zhou; David Rueda; Alessandro Costa
Source: check_circle
Crossref

Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution

Nature Communications
2015-12-18 | Journal article
DOI: 10.1038/ncomms10209
Contributors: Gayan Senavirathne; Jeffrey G. Bertram; Malgorzata Jaszczur; Kathy R. Chaurasiya; Phuong Pham; Chi H. Mak; Myron F. Goodman; David Rueda
Source: check_circle
Crossref

Peer review (4 reviews for 4 publications/grants)

Review activity for Biochemistry. (1)
Review activity for Journal of the American Chemical Society. (1)
Review activity for Nature chemical biology. (1)
Review activity for Nature communications (1)
How many people are using ORCID?